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Association Between Egg Consumption and Dementia Risk in the EPIC-Spain Dementia Cohort
Hernando J Margara-Escudero, Raul Zamora-Ros, Izar de Villasante, Marta Crous-Bou, María-Dolores Chirlaque, Pilar Amiano, Javier Mar, Aurelio Barricarte et al.. Frontiers in nutrition, 2022-02-23
Topic: Health services, long-term care and technology
A total of 774 incident dementia cases were diagnosed and validated, of which 518 were Alzheimer's disease (AD). Data on egg consumption were estimated using a validated dietary history questionnaire at recruitment. Cox proportional hazards models, adjusted for confounders, were used in the analyses. No association was observed between egg consumption and either total dementia [hazard ratio between extreme quartiles (HRQ4vs.Q1: 1.05; 95% CI 0.85-1.31; p-trend = 0.93)] or AD (HRQ4vs.Q1 0.93; 95% CI 0.72-1.21; p-trend = 0.50) risks. After dividing the population by adherence to the relative Mediterranean diet (rMED) score, a borderline inverse association was found between egg intake and both total dementia (HRQ4vs.Q1: 0.52; 95% CI 0.30-0.90; p-trend = 0.10) and AD (HRQ4vs.Q1: 0.52; 95% CI 0.27-1.01; p-trend = 0.13) risks within participants with low adherence to rMED score. However, no association was observed in participants with medium and high adherence to rMED score. This prospective study suggests that egg consumption is associated with a reduced risk of dementia, and specifically of AD, in the adult population with low adherence to rMED score; whereas it has no impact in subjects with moderate and high MD adherence.
Key findings
- A total of 774 incident dementia cases were diagnosed and validated, of which 518 were Alzheimer's disease (AD).
- Data on egg consumption were estimated using a validated dietary history questionnaire at recruitment.
- Cox proportional hazards models, adjusted for confounders, were used in the analyses.
- No association was observed between egg consumption and either total dementia [hazard ratio between extreme quartiles (HRQ4vs.Q1: 1.05; 95% CI 0.85-1.31; p-trend = 0.93)] or AD (HRQ4vs.Q1 0.93; 95% CI 0.72-1.21; p-trend = 0.50) risks.
- After dividing the population by adherence to the relative Mediterranean diet (rMED) score, a borderline inverse association was found between egg intake and both total dementia (HRQ4vs.Q1: 0.52; 95% CI 0.30-0.90; p-trend = 0.10) and AD (HRQ4vs.Q1: 0.52; 95% CI 0.27-1.01; p-trend = 0.13) risks within participants with low adherence to rMED score.
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Study details
- Participants25,015
- Evidence strengthModerate
How this study scored 57/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 32 of the 56 points we could judge it on, which is 57 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Frontiers in nutrition) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 4 / 4 | 25,015 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35284440) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 32 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 32 of the 56 points we could judge it on is 57 out of 100. |
| Total | 57 / 100 | — |
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Margara-Escudero, H. J., Zamora-Ros, R., de Villasante, I., Crous-Bou, M., Chirlaque, M.-D., Amiano, P., et al. (2022). Association Between Egg Consumption and Dementia Risk in the EPIC-Spain Dementia Cohort. Frontiers in nutrition. https://doi.org/10.3389/fnut.2022.827307
Vancouver
Margara-Escudero HJ, Zamora-Ros R, de Villasante I, Crous-Bou M, Chirlaque M.-D, Amiano P, et al. Association Between Egg Consumption and Dementia Risk in the EPIC-Spain Dementia Cohort. Frontiers in nutrition. 2022. doi:10.3389/fnut.2022.827307. PMID: 35284440.
BibTeX
@article{margaraescudero2022-35284440,
author = {Margara-Escudero, Hernando J and Zamora-Ros, Raul and de Villasante, Izar and Crous-Bou, Marta and Chirlaque, María-Dolores and Amiano, Pilar and Mar, Javier and Barricarte, Aurelio and others},
title = {{Association Between Egg Consumption and Dementia Risk in the EPIC-Spain Dementia Cohort}},
journal = {Frontiers in nutrition},
year = {2022},
doi = {10.3389/fnut.2022.827307},
pmid = {35284440},
url = {https://doi.org/10.3389/fnut.2022.827307}
}
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