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Integrated Analysis Highlights the Immunosuppressive Role of TREM2+ Macrophages in Hepatocellular Carcinoma
Zhou L, Wang M, Guo H, Hou J, Zhang Y, Li M, Wu X, Chen X et al.. Frontiers in immunology, 2022-03-14
Topic: Brain proteins, microglia and lab models
Recently, attention has been focused on the central role of TREM2 in diverse pathologies. However, the role of TREM2 signaling in the tumor microenvironment of hepatocellular carcinoma (HCC) remains poorly understood. Herein, we systematically investigated the single-cell transcriptomes of human HCC tissues and found that TREM2 was predominantly expressed by a macrophage subpopulation enriched in tumor tissues that resemble lipid-associated macrophages (LAMs).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Zhou, L., Wang, M., Guo, H., Hou, J., Zhang, Y., Li, M., et al. (2022). Integrated Analysis Highlights the Immunosuppressive Role of TREM2+ Macrophages in Hepatocellular Carcinoma. Frontiers in immunology. https://doi.org/10.3389/fimmu.2022.848367
Vancouver
Zhou L, Wang M, Guo H, Hou J, Zhang Y, Li M, et al. Integrated Analysis Highlights the Immunosuppressive Role of TREM2+ Macrophages in Hepatocellular Carcinoma. Frontiers in immunology. 2022. doi:10.3389/fimmu.2022.848367. PMID: 35359989.
BibTeX
@article{zhou2022-35359989,
author = {Zhou, L. and Wang, M. and Guo, H. and Hou, J. and Zhang, Y. and Li, M. and Wu, X. and Chen, X. and others},
title = {{Integrated Analysis Highlights the Immunosuppressive Role of TREM2+ Macrophages in Hepatocellular Carcinoma}},
journal = {Frontiers in immunology},
year = {2022},
doi = {10.3389/fimmu.2022.848367},
pmid = {35359989},
url = {https://doi.org/10.3389/fimmu.2022.848367}
}
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Key findings
- However, the role of TREM2 signaling in the tumor microenvironment of hepatocellular carcinoma (HCC) remains poorly understood.
- Herein, we systematically investigated the single-cell transcriptomes of human HCC tissues and found that TREM2 was predominantly expressed by a macrophage subpopulation enriched in tumor tissues that resemble lipid-associated macrophages (LAMs).
- The accumulation of TREM2 + LAM-like cells in HCC was confirmed in two additional cohorts using scRNA-seq analysis and immunohistochemistry.
- High expression of TREM2 correlated with high infiltrating macrophage abundance and poor prognosis.
Why it matters
This analysis of human hepatocellular carcinoma tissues found TREM2 expressed mainly by a macrophage subpopulation resembling lipid-associated macrophages. It is about liver cancer and not Alzheimer's disease, so it has no implications for treating, curing or preventing Alzheimer's.
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Study details
- Evidence strengthLow
How this study scored 48/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Frontiers in immunology) |
| Journal's citation record | 3 / 4 | Frontiers in Immunology: journal h-index 352 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 85 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 14.2 citations a year over 6 year(s) since 2022 |
| Impact for its field and year | 3 / 6 | Cited 6.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 6 other studies in this library |
| Still being cited | 3 / 4 | Cited 58 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Lianghai Wang: h-index 23 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Nanjing University: institution h-index 850 (OpenAlex) |
| Multicenter collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35359989) |
| Free to read | 2 / 2 | Free to read |
| Total | 48 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.3389/fimmu.2022.848367
- PubMed: 35359989
- Original source →
- Free full text: Frontiers in Immunology →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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