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58/100

✓ Peer-reviewed alzhub usefulness score 58 out of 100. Long-term cohort studies

Topic: Risk, prevention and care in population studies

Background This study aimed to investigate the associations of grip strength with incidence and mortality from dementia and whether these associations differ by sociodemographic and lifestyle factors. Methods A total of 466 788 participants of the UK Biobank (median age 56.5 years, 54.5% women). The outcome was all-cause dementia incidence and mortality and the exposure was grip strength.

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APA 7th

Esteban-Cornejo, I., Ho, F. K., Petermann-Rocha, F., Lyall, D. M., Martinez-Gomez, D., Cabanas-Sánchez, V., et al. (2022). Handgrip strength and all-cause dementia incidence and mortality: findings from the UK Biobank prospective cohort study. Journal of cachexia, sarcopenia and muscle. https://doi.org/10.1002/jcsm.12857

Vancouver

Esteban-Cornejo I, Ho FK, Petermann-Rocha F, Lyall DM, Martinez-Gomez D, Cabanas-Sánchez V, et al. Handgrip strength and all-cause dementia incidence and mortality: findings from the UK Biobank prospective cohort study. Journal of cachexia, sarcopenia and muscle. 2022. doi:10.1002/jcsm.12857. PMID: 35445560.

BibTeX

@article{estebancornejo2022-35445560,
  author  = {Esteban-Cornejo, I. and Ho, F. K. and Petermann-Rocha, F. and Lyall, D. M. and Martinez-Gomez, D. and Cabanas-Sánchez, V. and Ortega, F. B. and Hillman, C. H. and others},
  title   = {{Handgrip strength and all-cause dementia incidence and mortality: findings from the UK Biobank prospective cohort study}},
  journal = {Journal of cachexia, sarcopenia and muscle},
  year    = {2022},
  doi     = {10.1002/jcsm.12857},
  pmid    = {35445560},
  url     = {https://doi.org/10.1002/jcsm.12857}
}

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Key findings

Methods A total of 466 788 participants of the UK Biobank (median age 56.5 years, 54.5% women).
The outcome was all-cause dementia incidence and mortality and the exposure was grip strength.
Grip strength was assessed using a Jamar J00105 hydraulic hand dynamometer.
Results Excluding the first 2 years of follow-up (landmark analysis), mean follow-up was 9.1 years (inter-quartile range: 8.3; 9.7) for incidence and 9.3 (inter-quartile range: 8.7; 10.0) for mortality.

Why it matters

This UK Biobank cohort study investigated whether grip strength is associated with dementia incidence and mortality. It examines an association with a physical measure, so it does not show that improving grip strength prevents or treats Alzheimer's disease.

Study details

Participants788
Effect size54.5%
Evidence strengthLow

How this study scored 58/100

Published in a peer-reviewed journal. Scored zero for study design and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of cachexia, sarcopenia and muscle)
Journal's citation record	2 / 4	Journal of Cachexia Sarcopenia and Muscle: journal h-index 150 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	3 / 5	2022 — within 6 year(s) of the newest study here
Sample size	2 / 4	788 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 106 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	17.7 citations a year over 6 year(s) since 2022
Impact for its field and year	4 / 6	Cited 12.4× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	1 / 6	Cited by 2 other studies in this library
Still being cited	3 / 4	Cited 75 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Carlos A. Celis-Morales: h-index 71 (OpenAlex, whole career)
Institution's track record	2 / 3	University of Glasgow: institution h-index 1,600 (OpenAlex)
Multicenter collaboration	3 / 3	OpenAlex lists 11 institution(s) in 5 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 35445560)
Free to read	2 / 2	Free to read
Total	58 / 100	—

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