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Delusional Severity Is Associated with Abnormal Texture in FLAIR MRI
Marc A Khoury, Mohamad-Ali Bahsoun, Ayad Fadhel, Shukrullah Shunbuli, Saanika Venkatesh, Abdollah Ghazvanchahi, Samir Mitha, Karissa Chan et al.. Brain sciences, 2022-05-05
Topic: Plasma and spinal-fluid biomarkers
Biomarkers were extracted from a total of 42 participants with longitudinal time points representing 164 imaging volumes. Significant associations were found for all three NABM biomarkers between delusion level 3 and level 1. Integrity was also sensitive enough to show differences between delusion level 1 and delusion level 2. A significant specified interaction was noted with severe delusions (level 3) and CSF tau for all imaging biomarkers (p < 0.01). APOE4 homozygotes were also significantly related to the biomarkers. Cognitively impaired older adults with more severe delusions have greater global brain disease burden in the WM and GM combined (NABM) as measured using FLAIR MRI. Relative to patients with mild delusions, tissue degeneration in the NABM was more pronounced in subjects with higher delusional symptoms, with a significant association with CSF tau. Future studies are required to establish potential tau-associated mechanisms of increased delusional severity.
Key findings
- Biomarkers were extracted from a total of 42 participants with longitudinal time points representing 164 imaging volumes.
- Significant associations were found for all three NABM biomarkers between delusion level 3 and level 1.
- Integrity was also sensitive enough to show differences between delusion level 1 and delusion level 2.
- A significant specified interaction was noted with severe delusions (level 3) and CSF tau for all imaging biomarkers (p < 0.01).
- APOE4 homozygotes were also significantly related to the biomarkers.
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Study details
- Study designlongitudinal study
- Participants24
- Evidence strengthModerate
How this study scored 64/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 36 of the 56 points we could judge it on, which is 64 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Brain sciences) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 1 / 4 | 24 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35624987) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 36 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 36 of the 56 points we could judge it on is 64 out of 100. |
| Total | 64 / 100 | — |
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Khoury, M. A., Bahsoun, M.-A., Fadhel, A., Shunbuli, S., Venkatesh, S., Ghazvanchahi, A., et al. (2022). Delusional Severity Is Associated with Abnormal Texture in FLAIR MRI. Brain sciences. https://doi.org/10.3390/brainsci12050600
Vancouver
Khoury MA, Bahsoun M.-A, Fadhel A, Shunbuli S, Venkatesh S, Ghazvanchahi A, et al. Delusional Severity Is Associated with Abnormal Texture in FLAIR MRI. Brain sciences. 2022. doi:10.3390/brainsci12050600. PMID: 35624987.
BibTeX
@article{khoury2022-35624987,
author = {Khoury, Marc A and Bahsoun, Mohamad-Ali and Fadhel, Ayad and Shunbuli, Shukrullah and Venkatesh, Saanika and Ghazvanchahi, Abdollah and Mitha, Samir and Chan, Karissa and others},
title = {{Delusional Severity Is Associated with Abnormal Texture in FLAIR MRI}},
journal = {Brain sciences},
year = {2022},
doi = {10.3390/brainsci12050600},
pmid = {35624987},
url = {https://doi.org/10.3390/brainsci12050600}
}
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