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42/100

✓ Peer-reviewed alzhub usefulness score 42 out of 100. Risk factors

Topic: Brain proteins, microglia and lab models

A total of 321 people with cirrhosis (60 years, 78% men, 75% non-Hispanic White, 24% non-Hispanic African American, 4% Hispanic) were included. 45% had prior HE and 56% MHE. For ADI, the national percentile was 49.1 ± 21.8 while the state decile was 6.1 ± 2.3. ADI was not associated with race, ethnicity, MELD, or HE-related variables on regression. Regarding microbiota, α-diversity was lower in MHE and prior HE patients but similar across ADI rankings. Low vs high ADIs were associated with different β-diversity in univariable but not multivariable analyses. Multivariable analyses showed positive associations with MELD, prior HE, and lactate producers ( Lactobacillus and Lacticaseibacillus ) and negative associations with short-chain fatty acid producers ( Blautia , Lachnoclostridium , and Anaerobutyricum ) with MHE. Cirrhosis-related variables may be more influential in determining gut microbiome composition and cognitive impairment than ADI. Therefore, the focus should be on improving cirrhosis care, regardless of ADI, but studies evaluating other measures of social determinants are needed in cirrhosis.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Bajaj, J. S., Fagan, A., McGeorge, S., Sterling, R. K., Rogal, S. S., Sikaroodi, M., et al. (2022). Area Deprivation Index and Gut-Brain Axis in Cirrhosis. Clinical and Translational Gastroenterology. https://doi.org/10.14309/ctg.0000000000000495

Vancouver

Bajaj JS, Fagan A, McGeorge S, Sterling RK, Rogal SS, Sikaroodi M, et al. Area Deprivation Index and Gut-Brain Axis in Cirrhosis. Clinical and Translational Gastroenterology. 2022. doi:10.14309/ctg.0000000000000495. PMID: 35537854.

BibTeX

@article{bajaj2022-35537854,
  author  = {Bajaj, Jasmohan Singh and Fagan, Andrew and McGeorge, Sara and Sterling, Richard K. and Rogal, Shari S. and Sikaroodi, Masoumeh and Gillevet, Patrick Martin},
  title   = {{Area Deprivation Index and Gut-Brain Axis in Cirrhosis}},
  journal = {Clinical and Translational Gastroenterology},
  year    = {2022},
  doi     = {10.14309/ctg.0000000000000495},
  pmid    = {35537854},
  url     = {https://doi.org/10.14309/ctg.0000000000000495}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

Key findings

A total of 321 people with cirrhosis (60 years, 78% men, 75% non-Hispanic White, 24% non-Hispanic African American, 4% Hispanic) were included. 45% had prior HE and 56% MHE.
For ADI, the national percentile was 49.1 ± 21.8 while the state decile was 6.1 ± 2.3.
ADI was not associated with race, ethnicity, MELD, or HE-related variables on regression.
Regarding microbiota, α-diversity was lower in MHE and prior HE patients but similar across ADI rankings.
Low vs high ADIs were associated with different β-diversity in univariable but not multivariable analyses.

Why it matters

This study found that the Area Deprivation Index was not associated with gut microbiome composition or cognitive impairment in people with cirrhosis, and that cirrhosis-related variables may be more influential. It does not test a dementia treatment or prevention, so it cannot show how to cure or prevent dementia.

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Study details

Participants321
Evidence strengthLow

How this study scored 42/100

Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Clinical and Translational Gastroenterology)
Journal's citation record	1 / 4	Clinical and Translational Gastroenterology: journal h-index 78 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	3 / 5	2022 — within 6 year(s) of the newest study here
Sample size	2 / 4	321 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	2 / 7	Cited 9 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	1.5 citations a year over 6 year(s) since 2022
Impact for its field and year	1 / 6	Cited 0.9× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 8 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Patrick Martin Gillevet: h-index 68 (OpenAlex, whole career)
Institution's track record	1 / 3	University of Pittsburgh: institution h-index 1,470 (OpenAlex)
Multicenter collaboration	2 / 3	OpenAlex lists 5 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 35537854)
Free to read	2 / 2	Free to read
Total	42 / 100	—

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