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Alterations to cognitive abilities and functional networks in rats post broad-band intense noise exposure
Xiao-Min Xu, Yu-Qun Zhang, Feng-Chao Zang, Chun-Qiang Lu, Li-Jie Liu, Jian Wang, Richard Salvi, Yu-Chen Chen et al.. Brain imaging and behavior, 2022-05-11
Topic: Brain imaging, connectivity and assessment
This study aimed to investigate the alterations of cognition and functional connectivity post noise, and find the progress and neural substrates of noise induced hearing loss (NIHL)-associated cognitive impairment. We exposed rats to 122 dB broad-band noise for 2 h to induce hearing loss and the auditory function was assessed by measuring auditory brainstem response thresholds. Morris water maze test and resting state MRI were computed at 0 day, 1, 3, 6 months post noise to reveal cognitive ability and neural substrate. The interregional connections in the auditory network and default mode network, as well as the connections using the auditory cortex and cingulate cortex as seeds were also examined addtionally. The deficit in spatial learning/memory was only observed at 6 months after noise exposure. The internal connections in the auditory network and default mode network were enhanced at 0 day and decreased at 6 months post noise. The connectivity using the auditory cortex and cingulate cortex as seeds generally followed the rule of "enhancement-normal-decrease-widely decrease". A new model accounting for arousal, dementia, motor control of NIHL in is proposed. Our study highlights the fundamental flexibility of neural systems, and may also point toward novel therapeutic strategies for treating sensory disorders.
Key findings
- The deficit in spatial learning/memory was only observed at 6 months after noise exposure.
- The internal connections in the auditory network and default mode network were enhanced at 0 day and decreased at 6 months post noise.
- The connectivity using the auditory cortex and cingulate cortex as seeds generally followed the rule of "enhancement-normal-decrease-widely decrease".
- A new model accounting for arousal, dementia, motor control of NIHL in is proposed.
- Our study highlights the fundamental flexibility of neural systems, and may also point toward novel therapeutic strategies for treating sensory disorders.
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Study details
- Evidence strengthLow
How this study scored 41/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 23 of the 56 points we could judge it on, which is 41 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Brain imaging and behavior) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Laboratory or animal study (title names “rats”) — scores zero |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35543862) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 23 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 23 of the 56 points we could judge it on is 41 out of 100. |
| Total | 41 / 100 | — |
What each of these 20 components measures, and what this score is not →
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Xu, X.-M., Zhang, Y.-Q., Zang, F.-C., Lu, C.-Q., Liu, L.-J., Wang, J., et al. (2022). Alterations to cognitive abilities and functional networks in rats post broad-band intense noise exposure. Brain imaging and behavior. https://doi.org/10.1007/s11682-022-00643-8
Vancouver
Xu X.-M, Zhang Y.-Q, Zang F.-C, Lu C.-Q, Liu L.-J, Wang J, et al. Alterations to cognitive abilities and functional networks in rats post broad-band intense noise exposure. Brain imaging and behavior. 2022. doi:10.1007/s11682-022-00643-8. PMID: 35543862.
BibTeX
@article{xu2022-35543862,
author = {Xu, Xiao-Min and Zhang, Yu-Qun and Zang, Feng-Chao and Lu, Chun-Qiang and Liu, Li-Jie and Wang, Jian and Salvi, Richard and Chen, Yu-Chen and others},
title = {{Alterations to cognitive abilities and functional networks in rats post broad-band intense noise exposure}},
journal = {Brain imaging and behavior},
year = {2022},
doi = {10.1007/s11682-022-00643-8},
pmid = {35543862},
url = {https://doi.org/10.1007/s11682-022-00643-8}
}
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