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Lipid-associated macrophages in the tumor-adipose microenvironment facilitate breast cancer progression
Liu Z, Gao Z, Li B, Li J, Ou Y, Yu X, Zhang Z, Liu S et al.. Oncoimmunology, 2022-06-08
Topic: Brain proteins, microglia and lab models
The tumor-adipose microenvironment (TAME) is a universal microecosystem, that is characterized by the dysfunction of lipid metabolism, such as excessive free fatty acids (FFAs). Macrophages are the most abundant immune cell type within TAME, although their diversity in the TAME is not clear. We first reveal that infiltration of M2-like macrophages in the TAME is associated with poor survival in breast cancer.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Liu, Z., Gao, Z., Li, B., Li, J., Ou, Y., Yu, X., et al. (2022). Lipid-associated macrophages in the tumor-adipose microenvironment facilitate breast cancer progression. Oncoimmunology. https://doi.org/10.1080/2162402x.2022.2085432
Vancouver
Liu Z, Gao Z, Li B, Li J, Ou Y, Yu X, et al. Lipid-associated macrophages in the tumor-adipose microenvironment facilitate breast cancer progression. Oncoimmunology. 2022. doi:10.1080/2162402x.2022.2085432. PMID: 35712121.
BibTeX
@article{liu2022-35712121,
author = {Liu, Z. and Gao, Z. and Li, B. and Li, J. and Ou, Y. and Yu, X. and Zhang, Z. and Liu, S. and others},
title = {{Lipid-associated macrophages in the tumor-adipose microenvironment facilitate breast cancer progression}},
journal = {Oncoimmunology},
year = {2022},
doi = {10.1080/2162402x.2022.2085432},
pmid = {35712121},
url = {https://doi.org/10.1080/2162402x.2022.2085432}
}
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Key findings
- Macrophages are the most abundant immune cell type within TAME, although their diversity in the TAME is not clear.
- We first reveal that infiltration of M2-like macrophages in the TAME is associated with poor survival in breast cancer.
- To explore lipid-associated alterations in the TAME, we also detected the levels of FFAs transporters including fatty acid binding proteins (FABPs) and fatty acid transport protein 1 (FATP1).
- The results indicated that expression of fatty acid transporters in the TAME is tightly linked to the function of macrophages and predicts survival in breast cancer.
Why it matters
This study concerns the tumor-adipose microenvironment in breast cancer, reporting that M2-like macrophage infiltration is associated with poor survival. It concerns cancer, not Alzheimer's disease, and provides no information about treating, curing or preventing Alzheimer's disease.
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Study details
- Evidence strengthLow
How this study scored 47/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Oncoimmunology) |
| Journal's citation record | 2 / 4 | OncoImmunology: journal h-index 153 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 169 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 28.2 citations a year over 6 year(s) since 2022 |
| Impact for its field and year | 4 / 6 | Cited 10.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 3 / 4 | Cited 131 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Qi Wu: h-index 36 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Tongji University: institution h-index 628 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35712121) |
| Free to read | 2 / 2 | Free to read |
| Total | 47 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1080/2162402x.2022.2085432
- PubMed: 35712121
- Original source →
- Free full text: OncoImmunology →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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