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New Insights into Neuroinflammation Involved in Pathogenic Mechanism of Alzheimer's Disease and Its Potential for Therapeutic Intervention
Li T, Lu L, Pember E, Li X, Zhang B, Zhu Z.. Cells, 2022-06-14
Topic: Amyloid, tau and blood-test diagnosis
Alzheimer's disease (AD) is the most common form of dementia, affecting more than 50 million people worldwide with an estimated increase to 139 million people by 2050. The exact pathogenic mechanisms of AD remain elusive, resulting in the fact that the current therapeutics solely focus on symptomatic management instead of preventative or curative strategies. The two most widely accepted pathogenic mechanisms of AD include the amyloid and tau hypotheses.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Li, T., Lu, L., Pember, E., Li, X., Zhang, B., & Zhu, Z. (2022). New Insights into Neuroinflammation Involved in Pathogenic Mechanism of Alzheimer's Disease and Its Potential for Therapeutic Intervention. Cells. https://doi.org/10.3390/cells11121925
Vancouver
Li T, Lu L, Pember E, Li X, Zhang B, Zhu Z. New Insights into Neuroinflammation Involved in Pathogenic Mechanism of Alzheimer's Disease and Its Potential for Therapeutic Intervention. Cells. 2022. doi:10.3390/cells11121925. PMID: 35741054.
BibTeX
@article{li2022-35741054,
author = {Li, T. and Lu, L. and Pember, E. and Li, X. and Zhang, B. and Zhu, Z.},
title = {{New Insights into Neuroinflammation Involved in Pathogenic Mechanism of Alzheimer's Disease and Its Potential for Therapeutic Intervention}},
journal = {Cells},
year = {2022},
doi = {10.3390/cells11121925},
pmid = {35741054},
url = {https://doi.org/10.3390/cells11121925}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- The exact pathogenic mechanisms of AD remain elusive, resulting in the fact that the current therapeutics solely focus on symptomatic management instead of preventative or curative strategies.
- The two most widely accepted pathogenic mechanisms of AD include the amyloid and tau hypotheses.
- However, it is evident that these hypotheses cannot fully explain neuronal degeneration shown in AD.
- Substantial evidence is growing for the vital role of neuroinflammation in AD pathology.
Why it matters
This review notes that the exact pathogenic mechanisms of Alzheimer's disease remain elusive and that current therapeutics focus on symptomatic management rather than preventative or curative strategies. It discusses the growing evidence for neuroinflammation but does not report any treatment, cure, or prevention for Alzheimer's disease.
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Study details
- Evidence strengthLow
How this study scored 47/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Cells) |
| Journal's citation record | 2 / 4 | Cells: journal h-index 234 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 104 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 17.3 citations a year over 6 year(s) since 2022 |
| Impact for its field and year | 3 / 6 | Cited 6.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 4 other studies in this library |
| Still being cited | 3 / 4 | Cited 68 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Zheying Zhu: h-index 29 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Nottingham: institution h-index 879 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35741054) |
| Free to read | 2 / 2 | Free to read |
| Total | 47 / 100 | — |
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Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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