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58/100

✓ Peer-reviewed alzhub usefulness score 58 out of 100. Long-term cohort studies

Topic: Risk, prevention and care in population studies

Sedentary behavior (SB) is associated with cardiometabolic disease and mortality, but its association with dementia is currently unclear. This study investigates whether SB is associated with incident dementia regardless of engagement in physical activity (PA). A total of 146,651 participants from the UK Biobank who were 60 years or older and did not have a diagnosis of dementia (mean [SD] age: 64.59 [2.84] years) were included.

Key findings

This study investigates whether SB is associated with incident dementia regardless of engagement in physical activity (PA).
A total of 146,651 participants from the UK Biobank who were 60 years or older and did not have a diagnosis of dementia (mean [SD] age: 64.59 [2.84] years) were included.
Self-reported leisure-time SBs were divided into two domains: time spent watching television (TV) or time spent using a computer.
A total of 3,507 individuals were diagnosed with all-cause dementia over a mean follow-up of 11.87 (±1.17) years.

Why it matters

In this UK Biobank cohort, leisure-time sedentary behaviors such as television watching and computer use were tracked in people aged 60 or older, and 3,507 were diagnosed with all-cause dementia. The study examined whether these sedentary behaviors were linked to dementia regardless of how much physical activity people did.

Study details

Participants146,651
Evidence strengthLow

How this study scored 58/100

Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Proceedings of the National Academy of Sciences of the United States of America)
Journal's citation record	4 / 4	Proceedings of the National Academy of Sciences: journal h-index 1,167 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	3 / 5	2022 — within 6 year(s) of the newest study here
Sample size	4 / 4	146,651 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	4 / 7	Cited 84 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	14.0 citations a year over 6 year(s) since 2022
Impact for its field and year	4 / 6	Cited 8.9× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 3 other studies in this library
Still being cited	3 / 4	Cited 59 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Gene E. Alexander: h-index 80 (OpenAlex, whole career)
Institution's track record	2 / 3	University of Southern California: institution h-index 1,521 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 3 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 35994664)
Free to read	2 / 2	Free to read
Total	58 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

APA 7th

Raichlen, D. A., Klimentidis, Y. C., Sayre, M. K., Bharadwaj, P. K., Lai, M. H. C., Wilcox, R. R., et al. (2022). Leisure-time sedentary behaviors are differentially associated with all-cause dementia regardless of engagement in physical activity. Proceedings of the National Academy of Sciences of the United States of America. https://doi.org/10.1073/pnas.2206931119

Vancouver

Raichlen DA, Klimentidis YC, Sayre MK, Bharadwaj PK, Lai MHC, Wilcox RR, et al. Leisure-time sedentary behaviors are differentially associated with all-cause dementia regardless of engagement in physical activity. Proceedings of the National Academy of Sciences of the United States of America. 2022. doi:10.1073/pnas.2206931119. PMID: 35994664.

BibTeX

@article{raichlen2022-35994664,
  author  = {Raichlen, D. A. and Klimentidis, Y. C. and Sayre, M. K. and Bharadwaj, P. K. and Lai, M. H. C. and Wilcox, R. R. and Alexander, G. E.},
  title   = {{Leisure-time sedentary behaviors are differentially associated with all-cause dementia regardless of engagement in physical activity}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2022},
  doi     = {10.1073/pnas.2206931119},
  pmid    = {35994664},
  url     = {https://doi.org/10.1073/pnas.2206931119}
}

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