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Chinese Preclinical Alzheimer's Disease Study (C-PAS): Design and Challenge from PET Acceptance
L Cui, L Huang, F-F Pan, Y Wang, Q Huang, Y-H Guan, C-Y Z Lo, Y-H Guo et al.. The journal of prevention of Alzheimer's disease, 2023
Topic: Plasma and spinal-fluid biomarkers
There were 571 participants in the normal cognition group, 625 participants in the subjective cognitive decline group, 155 participants in the objectively defined subtle cognitive decline group, 501 participants in the mild cognitive impairment group, 471 participants in Alzheimer's disease group, and 128 participants with cognitive impairment from other known causes. Significant differences in demographics, florbetapir PET, APOE, and neuropsychological tests were found among the groups. Eight hundred and seventeen participants (33.3%) completed the florbetapir PET scanning. Non-demented individuals with higher age, lower education years, male, with a family history of dementia, and higher self-report depression prefer to undergo PET scans. Acceptance of PET scans did not correlate with objectively assessed cognitive impairment. The Chinese Preclinical Alzheimer's Disease Study was designed to establish a large-scale cohort with comprehensive data collection. Our findings may help to understand the factors affecting the acceptance of β-amyloid PET in urban areas of China and help us address the low acceptance challenge.
Key findings
- There were 571 participants in the normal cognition group, 625 participants in the subjective cognitive decline group, 155 participants in the objectively defined subtle cognitive decline group, 501 participants in the mild cognitive impairment group, 471 participants in Alzheimer's disease group, and 128 participants with cognitive impairment from other known causes.
- Significant differences in demographics, florbetapir PET, APOE, and neuropsychological tests were found among the groups.
- Eight hundred and seventeen participants (33.3%) completed the florbetapir PET scanning.
- Non-demented individuals with higher age, lower education years, male, with a family history of dementia, and higher self-report depression prefer to undergo PET scans.
- Acceptance of PET scans did not correlate with objectively assessed cognitive impairment.
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Study details
- Study designlongitudinal study
- Participants4,386
- Effect size33.3%
- Evidence strengthModerate
How this study scored 71/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 40 of the 56 points we could judge it on, which is 71 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (The journal of prevention of Alzheimer's disease) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 3 / 4 | 4,386 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 37357299) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 40 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 40 of the 56 points we could judge it on is 71 out of 100. |
| Total | 71 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Cui, L., Huang, L., Pan, F.-F., Wang, Y., Huang, Q., Guan, Y.-H., et al. (2023). Chinese Preclinical Alzheimer's Disease Study (C-PAS): Design and Challenge from PET Acceptance. The journal of prevention of Alzheimer's disease. https://doi.org/10.14283/jpad.2023.49
Vancouver
Cui L, Huang L, Pan F.-F, Wang Y, Huang Q, Guan Y.-H, et al. Chinese Preclinical Alzheimer's Disease Study (C-PAS): Design and Challenge from PET Acceptance. The journal of prevention of Alzheimer's disease. 2023. doi:10.14283/jpad.2023.49. PMID: 37357299.
BibTeX
@article{cui2023-37357299,
author = {Cui, L and Huang, L and Pan, F-F and Wang, Y and Huang, Q and Guan, Y-H and Lo, C-Y Z and Guo, Y-H and others},
title = {{Chinese Preclinical Alzheimer's Disease Study (C-PAS): Design and Challenge from PET Acceptance}},
journal = {The journal of prevention of Alzheimer's disease},
year = {2023},
doi = {10.14283/jpad.2023.49},
pmid = {37357299},
url = {https://doi.org/10.14283/jpad.2023.49}
}
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