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Weight Loss and Alzheimer's Disease in Down Syndrome
Victoria Fleming, Brian C Helsel, Lauren T Ptomey, H Diana Rosas, Benjamin Handen, Charles Laymon, Bradley T Christian, Elizabeth Head et al.. Journal of Alzheimer's disease : JAD, 2023
Topic: Brain imaging, connectivity and assessment
Polynomial regressions indicated an 0.23 kg/m2 decrease in BMI per year beginning at age 36.5 years, which occurs alongside the period during which Aβ and tau increase and memory and mental status decline. At a within-person level, elevated Aβ, decline in memory and mental status were associated with higher percent weight loss across 16-20 months. Unintentional weight loss occurs alongside Aβ deposition and prior to onset of AD dementia, and thus may be a useful sign of AD in DS.
Key findings
- Polynomial regressions indicated an 0.23 kg/m2 decrease in BMI per year beginning at age 36.5 years, which occurs alongside the period during which Aβ and tau increase and memory and mental status decline.
- At a within-person level, elevated Aβ, decline in memory and mental status were associated with higher percent weight loss across 16-20 months.
- Unintentional weight loss occurs alongside Aβ deposition and prior to onset of AD dementia, and thus may be a useful sign of AD in DS.
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Study details
- Participants77
- Evidence strengthModerate
How this study scored 52/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 29 of the 56 points we could judge it on, which is 52 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Alzheimer's disease : JAD) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 1 / 4 | 77 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 36565120) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 29 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 29 of the 56 points we could judge it on is 52 out of 100. |
| Total | 52 / 100 | — |
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Read the original
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Fleming, V., Helsel, B. C., Ptomey, L. T., Rosas, H. D., Handen, B., Laymon, C., et al. (2023). Weight Loss and Alzheimer's Disease in Down Syndrome. Journal of Alzheimer's disease : JAD. https://doi.org/10.3233/jad-220865
Vancouver
Fleming V, Helsel BC, Ptomey LT, Rosas HD, Handen B, Laymon C, et al. Weight Loss and Alzheimer's Disease in Down Syndrome. Journal of Alzheimer's disease : JAD. 2023. doi:10.3233/jad-220865. PMID: 36565120.
BibTeX
@article{fleming2023-36565120,
author = {Fleming, Victoria and Helsel, Brian C and Ptomey, Lauren T and Rosas, H Diana and Handen, Benjamin and Laymon, Charles and Christian, Bradley T and Head, Elizabeth and others},
title = {{Weight Loss and Alzheimer's Disease in Down Syndrome}},
journal = {Journal of Alzheimer's disease : JAD},
year = {2023},
doi = {10.3233/jad-220865},
pmid = {36565120},
url = {https://doi.org/10.3233/jad-220865}
}
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