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Association of gout with brain reserve and vulnerability to neurodegenerative disease
Anya Topiwala, Kulveer Mankia, Steven Bell, Alastair Webb, Klaus P Ebmeier, Isobel Howard, Chaoyue Wang, Fidel Alfaro-Almagro et al.. Nature communications, 2023-05-18
Topic: Brain imaging, connectivity and assessment
Studies of neurodegenerative disease risk in gout are contradictory. Relationships with neuroimaging markers of brain structure, which may offer insights, are uncertain. Here we investigated associations between gout, brain structure, and neurodegenerative disease incidence. Gout patients had smaller global and regional brain volumes and markers of higher brain iron, using both observational and genetic approaches. Participants with gout also had higher incidence of all-cause dementia, Parkinson's disease, and probable essential tremor. Risks were strongly time dependent, whereby associations with incident dementia were highest in the first 3 years after gout diagnosis. These findings suggest gout is causally related to several measures of brain structure. Lower brain reserve amongst gout patients may explain their higher vulnerability to multiple neurodegenerative diseases. Motor and cognitive impairments may affect gout patients, particularly in early years after diagnosis.
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APA 7th
Topiwala, A., Mankia, K., Bell, S., Webb, A., Ebmeier, K. P., Howard, I., et al. (2023). Association of gout with brain reserve and vulnerability to neurodegenerative disease. Nature communications. https://doi.org/10.1038/s41467-023-38602-6
Vancouver
Topiwala A, Mankia K, Bell S, Webb A, Ebmeier KP, Howard I, et al. Association of gout with brain reserve and vulnerability to neurodegenerative disease. Nature communications. 2023. doi:10.1038/s41467-023-38602-6. PMID: 37202397.
BibTeX
@article{topiwala2023-37202397,
author = {Topiwala, Anya and Mankia, Kulveer and Bell, Steven and Webb, Alastair and Ebmeier, Klaus P and Howard, Isobel and Wang, Chaoyue and Alfaro-Almagro, Fidel and others},
title = {{Association of gout with brain reserve and vulnerability to neurodegenerative disease}},
journal = {Nature communications},
year = {2023},
doi = {10.1038/s41467-023-38602-6},
pmid = {37202397},
url = {https://doi.org/10.1038/s41467-023-38602-6}
}
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Key findings
- These findings suggest gout is causally related to several measures of brain structure.
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Study details
- Evidence strengthLow
How this study scored 45/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 25 of the 56 points we could judge it on, which is 45 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Nature communications) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 37202397) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 25 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 25 of the 56 points we could judge it on is 45 out of 100. |
| Total | 45 / 100 | — |
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