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Plasma Aβ42/Aβ40 Ratios in Older People With Human Immunodeficiency Virus
Sarah A Cooley, Brittany Nelson, Anna Boerwinkle, Kevin E Yarasheski, Kris M Kirmess, Matthew R Meyer, Suzanne E Schindler, John C Morris et al.. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2023-05-24
Topic: Plasma and spinal-fluid biomarkers
The plasma Aβ42/Aβ40 ratio was significantly lower, and the APS higher, in PWoH_AD than in other groups. A lower Aβ42/Aβ40 ratio and higher APS was associated with smaller hippocampal volumes for PWoH_AD. The Aβ42/Aβ40 ratio and APS were not associated with cognition or HIV clinical measures for PWH. The plasma Aβ42/Aβ40 ratio can serve as a screening tool for AD and may help differentiate effects of HIV from AD within PWH, but larger studies with older PWH are needed.
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APA 7th
Cooley, S. A., Nelson, B., Boerwinkle, A., Yarasheski, K. E., Kirmess, K. M., Meyer, M. R., et al. (2023). Plasma Aβ42/Aβ40 Ratios in Older People With Human Immunodeficiency Virus. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. https://doi.org/10.1093/cid/ciad001
Vancouver
Cooley SA, Nelson B, Boerwinkle A, Yarasheski KE, Kirmess KM, Meyer MR, et al. Plasma Aβ42/Aβ40 Ratios in Older People With Human Immunodeficiency Virus. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2023. doi:10.1093/cid/ciad001. PMID: 36610788.
BibTeX
@article{cooley2023-36610788,
author = {Cooley, Sarah A and Nelson, Brittany and Boerwinkle, Anna and Yarasheski, Kevin E and Kirmess, Kris M and Meyer, Matthew R and Schindler, Suzanne E and Morris, John C and others},
title = {{Plasma Aβ42/Aβ40 Ratios in Older People With Human Immunodeficiency Virus}},
journal = {Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
year = {2023},
doi = {10.1093/cid/ciad001},
pmid = {36610788},
url = {https://doi.org/10.1093/cid/ciad001}
}
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Key findings
- The plasma Aβ42/Aβ40 ratio was significantly lower, and the APS higher, in PWoH_AD than in other groups.
- A lower Aβ42/Aβ40 ratio and higher APS was associated with smaller hippocampal volumes for PWoH_AD.
- The Aβ42/Aβ40 ratio and APS were not associated with cognition or HIV clinical measures for PWH.
- The plasma Aβ42/Aβ40 ratio can serve as a screening tool for AD and may help differentiate effects of HIV from AD within PWH, but larger studies with older PWH are needed.
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Study details
- Participants43
- Evidence strengthLow
How this study scored 48/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 27 of the 56 points we could judge it on, which is 48 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 1 / 4 | 43 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 36610788) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 27 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 27 of the 56 points we could judge it on is 48 out of 100. |
| Total | 48 / 100 | — |
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