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Primary retinal tauopathy: A tauopathy with a distinct molecular pattern
Grzegorz Walkiewicz, Alicja Ronisz, Rita Van Ginderdeuren, Sophie Lemmens, Femke H Bouwman, Jeroen J M Hoozemans, Tjado H J Morrema, Annemieke J Rozemuller et al.. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2023-08-24
Topic: Plasma and spinal-fluid biomarkers
Retinal p-tau pathology showed a consistent pattern with four stages and a molecular composition distinct from that of cerebral tauopathies. The stage of retinal p-tau pathology correlated with age (r = 0.176, P = 0.024) and was associated with AD (odds ratio [OR] 3.193; P = 0.001), and inflammation (OR = 2.605; P = 0.001). Vision impairment was associated with underlying eye diseases (β = 0.292; P = 0.001) and the stage of retinal p-tau pathology (β = 0.192; P = 0.030) in a linear regression model. The results show the presence of a primary retinal tauopathy that is distinct from cerebral tauopathies.
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APA 7th
Walkiewicz, G., Ronisz, A., Van Ginderdeuren, R., Lemmens, S., Bouwman, F. H., Hoozemans, J. J. M., et al. (2024). Primary retinal tauopathy: A tauopathy with a distinct molecular pattern. Alzheimer's & dementia : the journal of the Alzheimer's Association. https://doi.org/10.1002/alz.13424
Vancouver
Walkiewicz G, Ronisz A, Van Ginderdeuren R, Lemmens S, Bouwman FH, Hoozemans JJM, et al. Primary retinal tauopathy: A tauopathy with a distinct molecular pattern. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024. doi:10.1002/alz.13424. PMID: 37615275.
BibTeX
@article{walkiewicz2024-37615275,
author = {Walkiewicz, Grzegorz and Ronisz, Alicja and Van Ginderdeuren, Rita and Lemmens, Sophie and Bouwman, Femke H and Hoozemans, Jeroen J M and Morrema, Tjado H J and Rozemuller, Annemieke J and others},
title = {{Primary retinal tauopathy: A tauopathy with a distinct molecular pattern}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2024},
doi = {10.1002/alz.13424},
pmid = {37615275},
url = {https://doi.org/10.1002/alz.13424}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Retinal p-tau pathology showed a consistent pattern with four stages and a molecular composition distinct from that of cerebral tauopathies.
- The stage of retinal p-tau pathology correlated with age (r = 0.176, P = 0.024) and was associated with AD (odds ratio [OR] 3.193; P = 0.001), and inflammation (OR = 2.605; P = 0.001).
- Vision impairment was associated with underlying eye diseases (β = 0.292; P = 0.001) and the stage of retinal p-tau pathology (β = 0.192; P = 0.030) in a linear regression model.
- The results show the presence of a primary retinal tauopathy that is distinct from cerebral tauopathies.
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Study details
- Participants164
- Effect sizeOR = 2.605
- Evidence strengthLow
How this study scored 61/100
Published in a leading specialty journal. Scored zero for study design and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 34 of the 56 points we could judge it on, which is 61 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia : the journal of the Alzheimer's Association) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 164 participants |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 37615275) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 34 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 34 of the 56 points we could judge it on is 61 out of 100. |
| Total | 61 / 100 | — |
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