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Implications of gut and oral microbiota in neuroinflammatory responses in Alzheimer's disease
Bello-Corral L, Alves-Gomes L, Fernández-Fernández JA, Fernández-García D, Casado-Verdejo I, Sánchez-Valdeón L.. Life sciences, 2023-10-02
Topic: Amyloid, tau and blood-test diagnosis
A diverse and stable microbiota promotes a healthy state, nevertheless, an imbalance in gut or oral bacterial composition, called dysbiosis, can cause gastrointestinal disorders, systemic inflammatory states and oxidative stress, among others. Recently, gut and oral dysbiosis has been linked to Alzheimer's disease (AD), which is considered the most common form of dementia and a public health priority due to its high prevalence and incidence. The aim of this review is to highlight the implications of gut and oral microbiota in the neuroinflammation characteristic of AD pathology and the subsequent cognitive impairment. It is a systematic review of the current literature obtained by searching the PubMed, Web of Science and Scopus databases. The characteristic intestinal dysbiosis in AD patients leads to increased permeability of the intestinal barrier and activates immune cells in the central nervous system due to translocation of microbiota-derived metabolites and/or bacteria into the circulation leading to increased neuroinflammation and neuronal loss, thus generating the cognitive impairment characteristic of AD. The presence in the central nervous system of Porphyromonas gingivalis can cause an increased neuroinflammation and beta-amyloid peptide accumulation.
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APA 7th
Bello-Corral, L., Alves-Gomes, L., Fernández-Fernández, J. A., Fernández-García, D., Casado-Verdejo, I., & Sánchez-Valdeón, L. (2023). Implications of gut and oral microbiota in neuroinflammatory responses in Alzheimer's disease. Life sciences. https://doi.org/10.1016/j.lfs.2023.122132
Vancouver
Bello-Corral L, Alves-Gomes L, Fernández-Fernández JA, Fernández-García D, Casado-Verdejo I, Sánchez-Valdeón L. Implications of gut and oral microbiota in neuroinflammatory responses in Alzheimer's disease. Life sciences. 2023. doi:10.1016/j.lfs.2023.122132. PMID: 37793482.
BibTeX
@article{bellocorral2023-37793482,
author = {Bello-Corral, L. and Alves-Gomes, L. and Fernández-Fernández, J. A. and Fernández-García, D. and Casado-Verdejo, I. and Sánchez-Valdeón, L.},
title = {{Implications of gut and oral microbiota in neuroinflammatory responses in Alzheimer's disease}},
journal = {Life sciences},
year = {2023},
doi = {10.1016/j.lfs.2023.122132},
pmid = {37793482},
url = {https://doi.org/10.1016/j.lfs.2023.122132}
}
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Key findings
- Recently, gut and oral dysbiosis has been linked to Alzheimer's disease (AD), which is considered the most common form of dementia and a public health priority due to its high prevalence and incidence.
- The aim of this review is to highlight the implications of gut and oral microbiota in the neuroinflammation characteristic of AD pathology and the subsequent cognitive impairment.
- It is a systematic review of the current literature obtained by searching the PubMed, Web of Science and Scopus databases.
- The characteristic intestinal dysbiosis in AD patients leads to increased permeability of the intestinal barrier and activates immune cells in the central nervous system due to translocation of microbiota-derived metabolites and/or bacteria into the circulation leading to increased neuroinflammation and neuronal loss, thus generating the cognitive impairment characteristic of AD.
- The presence in the central nervous system of Porphyromonas gingivalis can cause an increased neuroinflammation and beta-amyloid peptide accumulation.
Why it matters
This review examines how an imbalance in gut or mouth bacteria may feed the brain inflammation seen in Alzheimer's. It describes a leaky gut barrier letting bacterial products into the blood and activating immune cells in the brain, and notes that the mouth bacterium Porphyromonas gingivalis in the brain can increase inflammation and beta-amyloid build-up. It summarizes proposed mechanisms rather than testing any treatment.
Study details
- Study designsystematic review
- Evidence strengthHigh
How this study scored 58/100
Published in a peer-reviewed journal, and it is a systematic review of all the studies on the question. Scored zero for sample size, effect reported and studied in people because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Life sciences) |
| Journal's citation record | 3 / 4 | Life Sciences: journal h-index 288 (OpenAlex, 2026-10-29) |
| Study design | 12 / 12 | A systematic review of all the studies on the question |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | A review of other studies — randomization is not credited here |
| Times cited | 4 / 7 | Cited 60 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 12.0 citations a year over 5 year(s) since 2023 |
| Impact for its field and year | 3 / 6 | Cited 4.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 2 other studies in this library |
| Still being cited | 3 / 4 | Cited 59 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Leticia Sánchez-Valdeón: h-index 8 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | University of Minho: institution h-index 476 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 37793482) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 58 / 100 | — |
What each of these 20 components measures, and what this score is not →
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