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Interaction Between Arteriosclerosis and Amyloid-β on Cognitive Function
Ingeborg Frentz, Joyce van Arendonk, Anna E Leeuwis, Meike W Vernooij, Wiesje M van der Flier, Daniel Bos, Peter Paul De Deyn, Frank J Wolters et al.. Journal of Alzheimer's disease : JAD, 2024
Topic: Brain imaging, connectivity and assessment
Amyloid-β (Aβ)42 and arterial calcification were associated with cognitive performance. After further adjustment for confounders in a model that combined all biomarkers, only arterial calcification remained independently associated with cognition. There was a significant interaction between arterial calcification and Aβ42 and between arterial calcification and the ratio of Aβ42/40. Yet, estimates attenuated, and interactions were no longer statistically significant after adjustment for cardio metabolic risk factors. Arteriosclerosis and AD display additive interaction-effects on cognition in the general population, that are due in part to cardio metabolic risk factors. These findings suggest that joint assessment of arteriosclerosis and AD pathology is important for understanding of disease etiology in individuals with cognitive impairment.
Key findings
- Amyloid-β (Aβ)42 and arterial calcification were associated with cognitive performance.
- After further adjustment for confounders in a model that combined all biomarkers, only arterial calcification remained independently associated with cognition.
- There was a significant interaction between arterial calcification and Aβ42 and between arterial calcification and the ratio of Aβ42/40.
- Yet, estimates attenuated, and interactions were no longer statistically significant after adjustment for cardio metabolic risk factors.
- Arteriosclerosis and AD display additive interaction-effects on cognition in the general population, that are due in part to cardio metabolic risk factors.
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Study details
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 24 of the 56 points we could judge it on, which is 43 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Alzheimer's disease : JAD) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 38217596) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 24 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 24 of the 56 points we could judge it on is 43 out of 100. |
| Total | 43 / 100 | — |
What each of these 20 components measures, and what this score is not →
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Frentz, I., van Arendonk, J., Leeuwis, A. E., Vernooij, M. W., van der Flier, W. M., Bos, D., et al. (2024). Interaction Between Arteriosclerosis and Amyloid-β on Cognitive Function. Journal of Alzheimer's disease : JAD. https://doi.org/10.3233/jad-230604
Vancouver
Frentz I, van Arendonk J, Leeuwis AE, Vernooij MW, van der Flier WM, Bos D, et al. Interaction Between Arteriosclerosis and Amyloid-β on Cognitive Function. Journal of Alzheimer's disease : JAD. 2024. doi:10.3233/jad-230604. PMID: 38217596.
BibTeX
@article{frentz2024-38217596,
author = {Frentz, Ingeborg and van Arendonk, Joyce and Leeuwis, Anna E and Vernooij, Meike W and van der Flier, Wiesje M and Bos, Daniel and De Deyn, Peter Paul and Wolters, Frank J and others},
title = {{Interaction Between Arteriosclerosis and Amyloid-β on Cognitive Function}},
journal = {Journal of Alzheimer's disease : JAD},
year = {2024},
doi = {10.3233/jad-230604},
pmid = {38217596},
url = {https://doi.org/10.3233/jad-230604}
}
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