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Alzheimer's Disease Puzzle: Delving into Pathogenesis Hypotheses
Nasb M, Tao W, Chen N.. Aging and disease, 2024-02-01
Topic: Amyloid, tau and blood-test diagnosis
Alzheimer's disease (AD) is a prevalent neurodegenerative disease characterized by both amnestic and non-amnestic clinical manifestations. It accounts for approximately 60-70% of all dementia cases worldwide. With the increasing number of AD patients, elucidating underlying mechanisms and developing corresponding interventional strategies are necessary.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Nasb, M., Tao, W., & Chen, N. (2024). Alzheimer's Disease Puzzle: Delving into Pathogenesis Hypotheses. Aging and disease. https://doi.org/10.14336/ad.2023.0608
Vancouver
Nasb M, Tao W, Chen N. Alzheimer's Disease Puzzle: Delving into Pathogenesis Hypotheses. Aging and disease. 2024. doi:10.14336/ad.2023.0608. PMID: 37450931.
BibTeX
@article{nasb2024-37450931,
author = {Nasb, M. and Tao, W. and Chen, N.},
title = {{Alzheimer's Disease Puzzle: Delving into Pathogenesis Hypotheses}},
journal = {Aging and disease},
year = {2024},
doi = {10.14336/ad.2023.0608},
pmid = {37450931},
url = {https://doi.org/10.14336/ad.2023.0608}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- It accounts for approximately 60-70% of all dementia cases worldwide.
- With the increasing number of AD patients, elucidating underlying mechanisms and developing corresponding interventional strategies are necessary.
- Hypotheses about AD such as amyloid cascade, Tau hyper-phosphorylation, neuroinflammation, oxidative stress, mitochondrial dysfunction, cholinergic, and vascular hypotheses are not mutually exclusive, and all of them play a certain role in the development of AD.
- The amyloid cascade hypothesis is currently the most widely studied; however, other hypotheses are also gaining support.
Why it matters
This review notes that several proposed mechanisms for Alzheimer's disease, including amyloid, tau, neuroinflammation, oxidative stress, mitochondrial dysfunction, cholinergic and vascular hypotheses, are not mutually exclusive and all appear to play some role. It does not report any treatment, cure or prevention result, only the need to clarify these mechanisms to develop future interventions.
Study details
- Evidence strengthLow
How this study scored 49/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Aging and disease) |
| Journal's citation record | 1 / 4 | Aging and Disease: journal h-index 107 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 165 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 41.2 citations a year over 4 year(s) since 2024 |
| Impact for its field and year | 5 / 6 | Cited 24.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 6 other studies in this library |
| Still being cited | 3 / 4 | Cited 159 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Ning Chen: h-index 62 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Wuhan Sports University: institution h-index 91 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 37450931) |
| Free to read | 2 / 2 | Free to read |
| Total | 49 / 100 | — |
What each of these 20 components measures, and what this score is not →
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