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60/100

✓ Peer-reviewed alzhub usefulness score 60 out of 100. Biomarkers

Topic: Amyloid, tau and blood-test diagnosis

Results Participants were 364 patients with PD and 168 controls, with comparable baseline mean (±SD) age (patients with PD = 62 ± 10 years; controls = 61 ± 11 years]; Mann-Whitney Wilcoxon: p = 0.4) and sex distribution (patients with PD = 231 male individuals [63%]; controls = 107 male individuals [64%]; χ 2 : p = 1). Patients with PD had overall lower CSF p-tau 181 (β = -0.16, 95% CI -0.23 to -0.092, p = 2.2e-05) and t-tau than controls (β = -0.13, 95% CI -0.19 to -0.065, p = 4e-04), but not Aβ 42 ( p = 0.061) or NfL ( p = 0.32). Discussion In patients with early PD, CSF p-tau 181 and t-tau were low compared with those in controls and did not increase over 5 years of follow-up.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Cousins, K. A. Q., Irwin, D. J., Tropea, T. F., Rhodes, E., Phillips, J., Chen-Plotkin, A. S., et al. (2024). Evaluation of ATNPD Framework and Biofluid Markers to Predict Cognitive Decline in Early Parkinson Disease. Neurology. https://doi.org/10.1212/wnl.0000000000208033

Vancouver

Cousins KAQ, Irwin DJ, Tropea TF, Rhodes E, Phillips J, Chen-Plotkin AS, et al. Evaluation of ATNPD Framework and Biofluid Markers to Predict Cognitive Decline in Early Parkinson Disease. Neurology. 2024. doi:10.1212/wnl.0000000000208033. PMID: 38306599.

BibTeX

@article{cousins2024-38306599,
  author  = {Cousins, K. A. Q. and Irwin, D. J. and Tropea, T. F. and Rhodes, E. and Phillips, J. and Chen-Plotkin, A. S. and Brumm, M. C. and Coffey, C. S. and others},
  title   = {{Evaluation of ATNPD Framework and Biofluid Markers to Predict Cognitive Decline in Early Parkinson Disease}},
  journal = {Neurology},
  year    = {2024},
  doi     = {10.1212/wnl.0000000000208033},
  pmid    = {38306599},
  url     = {https://doi.org/10.1212/wnl.0000000000208033}
}

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Key findings

Results Participants were 364 patients with PD and 168 controls, with comparable baseline mean (±SD) age (patients with PD = 62 ± 10 years; controls = 61 ± 11 years]; Mann-Whitney Wilcoxon: p = 0.4) and sex distribution (patients with PD = 231 male individuals [63%]; controls = 107 male individuals [64%]; χ 2 : p = 1).
Patients with PD had overall lower CSF p-tau 181 (β = -0.16, 95% CI -0.23 to -0.092, p = 2.2e-05) and t-tau than controls (β = -0.13, 95% CI -0.19 to -0.065, p = 4e-04), but not Aβ 42 ( p = 0.061) or NfL ( p = 0.32).
Discussion In patients with early PD, CSF p-tau 181 and t-tau were low compared with those in controls and did not increase over 5 years of follow-up.

Why it matters

In 364 people with early Parkinson disease, spinal fluid p-tau181 and t-tau were lower than in controls and did not rise over 5 years of follow-up. This concerns Parkinson disease markers and reports no increase in these Alzheimer-related tau measures.

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Study details

Study designlongitudinal study
Participants32
Evidence strengthModerate

How this study scored 60/100

Published in a leading specialty journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 58 of the 96 points we could judge it on, which is 60 out of 100.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (Neurology)
Journal's citation record	4 / 4	Neurology: journal h-index 525 (OpenAlex, 2026-10-29)
Study design	7 / 12	A longitudinal study following the same people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2024 — within 3 year(s) of the newest study here
Sample size	1 / 4	32 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	3 / 7	Cited 25 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	6.2 citations a year over 4 year(s) since 2024
Impact for its field and year	3 / 6	Cited 5.8× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	1 / 6	Cited by 1 other studies in this library
Still being cited	2 / 4	Cited 25 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	— / 4	Senior author's record not available — left out of this score
Institution's track record	2 / 3	University of Pennsylvania: institution h-index 1,859 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 4 institution(s) in 2 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 38306599)
Free to read	0 / 2	Behind a paywall — scores zero
Points	58 / 96	Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 58 of the 96 points we could judge it on is 60 out of 100.
Total	60 / 100	—

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