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Cognitive and functional performance and plasma biomarkers of early Alzheimer's disease in Down syndrome
Emily K Schworer, Benjamin L Handen, Melissa Petersen, Sid O'Bryant, Jamie C Peven, Dana L Tudorascu, Laisze Lee, Sharon J Krinsky-McHale et al.. Alzheimer's & dementia (Amsterdam, Netherlands), 2024-04-14
Topic: Plasma and spinal-fluid biomarkers
In general linear models lower plasma Aβ42/40 was related to lower visuospatial ability, higher total tau was related to lower episodic memory, and higher NfL was related to lower visuospatial ability and lower episodic memory. Plasma biomarkers may have utility in tracking AD pathology associated with early stages of cognitive decline in adults with DS, although associations were modest. HIGHLIGHTS: Plasma Alzheimer's disease (AD) biomarkers correlate with cognition prior to dementia in Down syndrome.Lower plasma amyloid beta 42/40 was related to lower visuospatial abilities.Higher plasma total tau and neurofilament light chain were associated with lower cognitive performance.Plasma biomarkers show potential for tracking early stages of AD symptomology.
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APA 7th
Schworer, E. K., Handen, B. L., Petersen, M., O'Bryant, S., Peven, J. C., Tudorascu, D. L., et al. (2024). Cognitive and functional performance and plasma biomarkers of early Alzheimer's disease in Down syndrome. Alzheimer's & dementia (Amsterdam, Netherlands). https://doi.org/10.1002/dad2.12582
Vancouver
Schworer EK, Handen BL, Petersen M, O'Bryant S, Peven JC, Tudorascu DL, et al. Cognitive and functional performance and plasma biomarkers of early Alzheimer's disease in Down syndrome. Alzheimer's & dementia (Amsterdam, Netherlands). 2024. doi:10.1002/dad2.12582. PMID: 38623384.
BibTeX
@article{schworer2024-38623384,
author = {Schworer, Emily K and Handen, Benjamin L and Petersen, Melissa and O'Bryant, Sid and Peven, Jamie C and Tudorascu, Dana L and Lee, Laisze and Krinsky-McHale, Sharon J and others},
title = {{Cognitive and functional performance and plasma biomarkers of early Alzheimer's disease in Down syndrome}},
journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
year = {2024},
doi = {10.1002/dad2.12582},
pmid = {38623384},
url = {https://doi.org/10.1002/dad2.12582}
}
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Key findings
- In general linear models lower plasma Aβ42/40 was related to lower visuospatial ability, higher total tau was related to lower episodic memory, and higher NfL was related to lower visuospatial ability and lower episodic memory.
- Plasma biomarkers may have utility in tracking AD pathology associated with early stages of cognitive decline in adults with DS, although associations were modest.
- HIGHLIGHTS: Plasma Alzheimer's disease (AD) biomarkers correlate with cognition prior to dementia in Down syndrome.Lower plasma amyloid beta 42/40 was related to lower visuospatial abilities.Higher plasma total tau and neurofilament light chain were associated with lower cognitive performance.Plasma biomarkers show potential for tracking early stages of AD symptomology.
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Study details
- Study designcohort study
- Participants260
- Evidence strengthModerate
How this study scored 71/100
Published in a leading specialty journal, and it is a cohort study following people over time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 40 of the 56 points we could judge it on, which is 71 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia (Amsterdam, Netherlands)) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 260 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 38623384) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 40 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 40 of the 56 points we could judge it on is 71 out of 100. |
| Total | 71 / 100 | — |
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