Methotrexate and the Risk of Dementia: A Two-Sample Mendelian Randomization Study
Xiao-Na Ma, Wei Feng, Shu-Lin Chen, Xiao-Qin Zhong, Chang-Song Lin, Qiang Xu. Neurology and therapy, 2024-04-09
Topic: Drug trials: efficacy and safety
Our TSMR analysis showed a significant positive association between genetic predisposition to methotrexate use and dementia risk. The IVW method estimated a causal odds ratio (OR) of 0.476 [95% confidence interval (CI) 0.362-0.626] per unit increase in the log odds ratio of methotrexate use. WM1, WM2, and MR-Egger methods provided consistent results. The findings of this mendelian randomization (MR) study suggest a potential causal effect of methotrexate use on the risk of dementia. However, further research is needed to validate these findings and explore the underlying mechanisms. Since methotrexate is widely prescribed for various autoimmune diseases, a better understanding of its potential impact on dementia risk is crucial for optimizing treatment strategies and addressing potential adverse effects.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Ma, X.-N., Feng, W., Chen, S.-L., Zhong, X.-Q., Lin, C.-S., & Xu, Q. (2024). Methotrexate and the Risk of Dementia: A Two-Sample Mendelian Randomization Study. Neurology and therapy. https://doi.org/10.1007/s40120-024-00609-6
Vancouver
Ma X.-N, Feng W, Chen S.-L, Zhong X.-Q, Lin C.-S, Xu Q. Methotrexate and the Risk of Dementia: A Two-Sample Mendelian Randomization Study. Neurology and therapy. 2024. doi:10.1007/s40120-024-00609-6. PMID: 38592337.
BibTeX
@article{ma2024-38592337,
author = {Ma, Xiao-Na and Feng, Wei and Chen, Shu-Lin and Zhong, Xiao-Qin and Lin, Chang-Song and Xu, Qiang},
title = {{Methotrexate and the Risk of Dementia: A Two-Sample Mendelian Randomization Study}},
journal = {Neurology and therapy},
year = {2024},
doi = {10.1007/s40120-024-00609-6},
pmid = {38592337},
url = {https://doi.org/10.1007/s40120-024-00609-6}
}
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Key findings
- Our TSMR analysis showed a significant positive association between genetic predisposition to methotrexate use and dementia risk.
- The IVW method estimated a causal odds ratio (OR) of 0.476 [95% confidence interval (CI) 0.362-0.626] per unit increase in the log odds ratio of methotrexate use.
- WM1, WM2, and MR-Egger methods provided consistent results.
- The findings of this mendelian randomization (MR) study suggest a potential causal effect of methotrexate use on the risk of dementia.
- However, further research is needed to validate these findings and explore the underlying mechanisms.
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Study details
- Study designmeta-analysis
- Evidence strengthHigh
How this study scored 71/100
Published in a peer-reviewed journal, and it is a meta-analysis pooling many studies. Scored zero for sample size, effect reported and studied in people because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 40 of the 56 points we could judge it on, which is 71 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neurology and therapy) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 12 / 12 | A meta-analysis pooling many studies |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | A review of other studies — randomization is not credited here |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 38592337) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 40 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 40 of the 56 points we could judge it on is 71 out of 100. |
| Total | 71 / 100 | — |
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