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44/100

✓ Peer-reviewed alzhub usefulness score 44 out of 100. Brain scans and imaging

Topic: Plasma and spinal-fluid biomarkers

Plain-language summary

14 out of 16 regional conversions from [18F]Flutemetamol SUVr to Centiloid successfully passed the quality control, showing good reliability and relative variance, especially precuneus/posterior cingulate and prefrontal regions with good stability for Centiloid scaling. The absence of focal Aβ deposition could be detected by measuring regional CL, showing a high agreement rate with visual inspection. The regional Aβ positivity in the bilateral anterior cingulate cortex was most prevalent in equivocal cases. The expression of regional brain Aβ deposition in CL with [18F]Flutemetamol has been attempted in this study. Equivocal cases had focal Aβ deposition that can be detected by measuring regional CL.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Bao, Y.-W., Wang, Z.-J., Guo, L.-L., Bai, G.-J., Feng, Y., & Zhao, G.-D. (2024). Expression of regional brain amyloid-β deposition with [18F]Flutemetamol in Centiloid scale -a multi-site study. Neuroradiology. https://doi.org/10.1007/s00234-024-03364-5

Vancouver

Bao Y.-W, Wang Z.-J, Guo L.-L, Bai G.-J, Feng Y, Zhao G.-D. Expression of regional brain amyloid-β deposition with [18F]Flutemetamol in Centiloid scale -a multi-site study. Neuroradiology. 2024. doi:10.1007/s00234-024-03364-5. PMID: 38676749.

BibTeX

@article{bao2024-38676749,
  author  = {Bao, Yi-Wen and Wang, Zuo-Jun and Guo, Li-Li and Bai, Gen-Ji and Feng, Yun and Zhao, Guo-Dong},
  title   = {{Expression of regional brain amyloid-β deposition with [18F]Flutemetamol in Centiloid scale -a multi-site study}},
  journal = {Neuroradiology},
  year    = {2024},
  doi     = {10.1007/s00234-024-03364-5},
  pmid    = {38676749},
  url     = {https://doi.org/10.1007/s00234-024-03364-5}
}

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How to read this study

Design: our record does not state a study design, so check the methods section of the original before weighing the result.
Size: the record gives no participant count. Look for one in the original before trusting a pattern.
Effect: the record gives no effect size, so the summary above cannot say how large any difference was.

What the evidence grade means here

This page is graded low. alzhub.org assigns the grade automatically from keywords in the abstract, not from reading the paper. Low means the abstract matched neither pattern. It is the default label, and it does not mean the work is poor; many sound lab and imaging papers land here. It can add at most 5 of the 100 points in the study score, and it is a label about design, not a verdict on whether the findings are true.

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Key findings

14 out of 16 regional conversions from [18F]Flutemetamol SUVr to Centiloid successfully passed the quality control, showing good reliability and relative variance, especially precuneus/posterior cingulate and prefrontal regions with good stability for Centiloid scaling.
The absence of focal Aβ deposition could be detected by measuring regional CL, showing a high agreement rate with visual inspection.
The regional Aβ positivity in the bilateral anterior cingulate cortex was most prevalent in equivocal cases.
The expression of regional brain Aβ deposition in CL with [18F]Flutemetamol has been attempted in this study.
Equivocal cases had focal Aβ deposition that can be detected by measuring regional CL.

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Study details

Evidence strengthLow

How this study scored 44/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and free to read, so those were left out: it earned 26 of the 59 points we could judge it on, which is 44 out of 100.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Neuroradiology)
Journal's citation record	— / 4	No journal record from OpenAlex — left out of this score
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2024 — within 3 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	— / 7	No citation count (not found in OpenAlex) — left out of this score
Citations per year	— / 5	No citation count or no year — left out of this score
Impact for its field and year	— / 6	No field-weighted citation impact (OpenAlex has none yet) — left out of this score
Cited by studies here	— / 6	Not yet checked against this library's citation graph — left out of this score
Still being cited	— / 4	No yearly citation counts — left out of this score
Senior author's track record	— / 4	Senior author's record not available — left out of this score
Institution's track record	— / 3	No institution listed in OpenAlex — left out of this score
Multicenter collaboration	2 / 3	PubMed indexes it as a multicentre study
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 38676749)
Free to read	— / 2	Access not recorded — left out of this score
Points	26 / 59	Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 26 of the 59 points we could judge it on is 44 out of 100.
Total	44 / 100	—

What each of these 20 components measures, and what this score is not →

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