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Depressive Symptoms Are Not Associated with Predementia Cerebrospinal Fluid Amyloid Pathology
Cecilia Magdalena Eriksson, Bjørn-Eivind Kirsebom, Ragna Espenes, Nikias Siafarikas, Knut Waterloo, Arvid Rongve, Per Selnes, Dag Aarsland et al.. Dementia and geriatric cognitive disorders extra, 2024-05-10
Topic: Brain imaging, connectivity and assessment
Only the Aβ negative MCI group (MCI-Aβ-) was associated with depressive symptoms (odds ratio [OR] = 2.65, p = 0.005). Depressive symptoms were associated with worse memory in MCI-Aβ- (OR = 0.94, p = 0.039), but with better performance in MCI-Aβ+ (OR = 1.103, p = 0.001). Our results suggest that depressive symptoms in MCI are neither associated with Aβ pathology, nor AD-associated memory impairment. However, memory impairment in non-AD MCI may relate to depressive symptoms.
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APA 7th
Eriksson, C. M., Kirsebom, B.-E., Espenes, R., Siafarikas, N., Waterloo, K., Rongve, A., et al. (2024). Depressive Symptoms Are Not Associated with Predementia Cerebrospinal Fluid Amyloid Pathology. Dementia and geriatric cognitive disorders extra. https://doi.org/10.1159/000539284
Vancouver
Eriksson CM, Kirsebom B.-E, Espenes R, Siafarikas N, Waterloo K, Rongve A, et al. Depressive Symptoms Are Not Associated with Predementia Cerebrospinal Fluid Amyloid Pathology. Dementia and geriatric cognitive disorders extra. 2024. doi:10.1159/000539284. PMID: 38939101.
BibTeX
@article{eriksson2024-38939101,
author = {Eriksson, Cecilia Magdalena and Kirsebom, Bjørn-Eivind and Espenes, Ragna and Siafarikas, Nikias and Waterloo, Knut and Rongve, Arvid and Selnes, Per and Aarsland, Dag and others},
title = {{Depressive Symptoms Are Not Associated with Predementia Cerebrospinal Fluid Amyloid Pathology}},
journal = {Dementia and geriatric cognitive disorders extra},
year = {2024},
doi = {10.1159/000539284},
pmid = {38939101},
url = {https://doi.org/10.1159/000539284}
}
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Key findings
- Only the Aβ negative MCI group (MCI-Aβ-) was associated with depressive symptoms (odds ratio [OR] = 2.65, p = 0.005).
- Depressive symptoms were associated with worse memory in MCI-Aβ- (OR = 0.94, p = 0.039), but with better performance in MCI-Aβ+ (OR = 1.103, p = 0.001).
- Our results suggest that depressive symptoms in MCI are neither associated with Aβ pathology, nor AD-associated memory impairment.
- However, memory impairment in non-AD MCI may relate to depressive symptoms.
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Study details
- Participants160
- Effect sizeOR = 0.94; OR = 1.103
- Evidence strengthModerate
How this study scored 61/100
Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 34 of the 56 points we could judge it on, which is 61 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Dementia and geriatric cognitive disorders extra) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 160 participants |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 38939101) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 34 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 34 of the 56 points we could judge it on is 61 out of 100. |
| Total | 61 / 100 | — |
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