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Cerebrospinal fluid synaptic biomarker changes in bipolar disorder - A longitudinal case-control study
Ulla Knorr, Anja Hviid Simonsen, Johanna Nilsson, Ann Brinkmalm, Henrik Zetterberg, Kaj Blennow, Mark Bech Knudsen, Julie Forman et al.. Journal of affective disorders, 2024-05-07
Topic: Plasma and spinal-fluid biomarkers
The synaptic proteins revealed no statistically significant differences between BD and HC, neither at baseline, one-year follow-up, or in terms of changes from baseline to follow-up. Moreover, the CSF synaptic protein levels in patients with BD were unaltered compared to baseline when they stabilized in euthymia following an affective episode and at one-year follow-up. LIMITATION: It is uncertain what the CSF biomarker concentrations reflect since we yet do not know the mechanisms of release of these proteins, and we are uncertain of what increased or decreased levels reflect. This first-ever investigation of a panel of CSF protein biomarkers of synaptic dysfunction in patients with BD and HC individuals found no statistically significant differences cross-sectionally or longitudinally.
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APA 7th
Knorr, U., Simonsen, A. H., Nilsson, J., Brinkmalm, A., Zetterberg, H., Blennow, K., et al. (2024). Cerebrospinal fluid synaptic biomarker changes in bipolar disorder - A longitudinal case-control study. Journal of affective disorders. https://doi.org/10.1016/j.jad.2024.05.034
Vancouver
Knorr U, Simonsen AH, Nilsson J, Brinkmalm A, Zetterberg H, Blennow K, et al. Cerebrospinal fluid synaptic biomarker changes in bipolar disorder - A longitudinal case-control study. Journal of affective disorders. 2024. doi:10.1016/j.jad.2024.05.034. PMID: 38723679.
BibTeX
@article{knorr2024-38723679,
author = {Knorr, Ulla and Simonsen, Anja Hviid and Nilsson, Johanna and Brinkmalm, Ann and Zetterberg, Henrik and Blennow, Kaj and Knudsen, Mark Bech and Forman, Julie and others},
title = {{Cerebrospinal fluid synaptic biomarker changes in bipolar disorder - A longitudinal case-control study}},
journal = {Journal of affective disorders},
year = {2024},
doi = {10.1016/j.jad.2024.05.034},
pmid = {38723679},
url = {https://doi.org/10.1016/j.jad.2024.05.034}
}
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Key findings
- The synaptic proteins revealed no statistically significant differences between BD and HC, neither at baseline, one-year follow-up, or in terms of changes from baseline to follow-up.
- Moreover, the CSF synaptic protein levels in patients with BD were unaltered compared to baseline when they stabilized in euthymia following an affective episode and at one-year follow-up.
- LIMITATION: It is uncertain what the CSF biomarker concentrations reflect since we yet do not know the mechanisms of release of these proteins, and we are uncertain of what increased or decreased levels reflect.
- This first-ever investigation of a panel of CSF protein biomarkers of synaptic dysfunction in patients with BD and HC individuals found no statistically significant differences cross-sectionally or longitudinally.
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Study details
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 24 of the 56 points we could judge it on, which is 43 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of affective disorders) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 38723679) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 24 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 24 of the 56 points we could judge it on is 43 out of 100. |
| Total | 43 / 100 | — |
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