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Associations between vision impairment and eye diseases with dementia, dementia subtypes and cognitive impairment: An umbrella review
Masoud Rahmati, Lee Smith, Hyeri Lee, Laurent Boyer, Guillaume Fond, Dong Keon Yon, Hayeon Lee, Pinar Soysal et al.. Ageing research reviews, 2024-10-05
Topic: Brain imaging, connectivity and assessment
Vision impairment (VI) and eye diseases such as age-related macular degeneration (AMD), diabetic retinopathy (DR), glaucoma and cataract have been reported to be associated with cognitive impairment and dementia, however, to date, very little attempt has been made to collate and synthesizes such literature. Therefore, the aim of this umbrella review is to systematically assesses the credibility and certainty of evidence of associations between vision impairment (VI) and eye diseases with cognitive impairment, dementia and dementia subtypes. We conducted an umbrella review of meta-analyses by screening articles in any language in PubMed, MEDLINE (Ovid), EMBASE, Web of Science, Cochrane CENTRAL and CDSR published from database inception up to May 30, 2024. Quality appraisal of each included original meta-analysis was assessed using A Measurement Tool for Assessing Systematic Reviews 2 (AMSTAR2). The certainty of the evidence was based on statistical significance, study size, heterogeneity, small study effects, prediction intervals (PI), and bias. We followed an a-priori protocol registered with PROSPERO (CRD42024564249). We identified 13 meta-analyses (AMSTAR 2; high accuracy of the findings 1, moderate 10, and low 2) that included 232 original articles based on 99,337,354 participants. Overall, no evidence was highly suggestive or convincing. Suggestive evidence was found for associations between cataract and dementia (equivalent odds ratio [eOR] 1.20, 95 %CI, 1.16-1.25), cataract and Alzheimer's disease (eOR 1.21, 95 %CI, 1.15-1.28), and AMD and Alzheimer's disease (eOR 1.27, 95 %CI, 1.27-1.27). Weak evidence was found for associations between VI and dementia (eOR 1.50, 95 %CI, 1.23-1.84), DR and dementia (eOR 1.33, 95 %CI, 1.17-1.50), cataract and vascular dementia (eOR 1.26, 95 %CI, 1.09-1.45), VI identified by cross-sectional studies and cognitive impairment (eOR 2.37, 95 %CI, 2.31-2.44), and VI identified by objective measures and cognitive impairment (eOR 1.56, 95 %CI, 1.12-2.18). The observed suggestive level of evidence for the relationship between eye disease and dementia (as well as dementia subtypes) suggests that policy and interventions to aid in the prevention and management of eye disease may also aid in the prevention of dementia syndrome. Where the level of evidence is weak, further studies are needed with stronger methodological approaches.
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APA 7th
Rahmati, M., Smith, L., Lee, H., Boyer, L., Fond, G., Yon, D. K., et al. (2024). Associations between vision impairment and eye diseases with dementia, dementia subtypes and cognitive impairment: An umbrella review. Ageing research reviews. https://doi.org/10.1016/j.arr.2024.102523
Vancouver
Rahmati M, Smith L, Lee H, Boyer L, Fond G, Yon DK, et al. Associations between vision impairment and eye diseases with dementia, dementia subtypes and cognitive impairment: An umbrella review. Ageing research reviews. 2024. doi:10.1016/j.arr.2024.102523. PMID: 39369799.
BibTeX
@article{rahmati2024-39369799,
author = {Rahmati, Masoud and Smith, Lee and Lee, Hyeri and Boyer, Laurent and Fond, Guillaume and Yon, Dong Keon and Lee, Hayeon and Soysal, Pinar and others},
title = {{Associations between vision impairment and eye diseases with dementia, dementia subtypes and cognitive impairment: An umbrella review}},
journal = {Ageing research reviews},
year = {2024},
doi = {10.1016/j.arr.2024.102523},
pmid = {39369799},
url = {https://doi.org/10.1016/j.arr.2024.102523}
}
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Key findings
- Vision impairment (VI) and eye diseases such as age-related macular degeneration (AMD), diabetic retinopathy (DR), glaucoma and cataract have been reported to be associated with cognitive impairment and dementia, however, to date, very little attempt has been made to collate and synthesizes such literature.
- Overall, no evidence was highly suggestive or convincing.
- The observed suggestive level of evidence for the relationship between eye disease and dementia (as well as dementia subtypes) suggests that policy and interventions to aid in the prevention and management of eye disease may also aid in the prevention of dementia syndrome.
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Study details
- Study designmeta-analysis
- Participants232
- Effect sizeOR 1.21; OR 1.27; OR 1.50
- Evidence strengthHigh
How this study scored 86/100
Published in a peer-reviewed journal, and it is a meta-analysis pooling many studies. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 48 of the 56 points we could judge it on, which is 86 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Ageing research reviews) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 12 / 12 | A meta-analysis pooling many studies |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 232 participants |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | A review of other studies — randomisation is not credited here |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39369799) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 48 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 48 of the 56 points we could judge it on is 86 out of 100. |
| Total | 86 / 100 | — |
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