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41/100

✓ Peer-reviewed alzhub usefulness score 41 out of 100. Health systems and care delivery

Topic: Amyloid, tau and blood-test diagnosis

In FFS, AD incidence (2008-2018) decreased (138 to 104); MCI incidence increased (8 to 47), but the sum (MCI + AD) was relatively stable (146 to 151). Prevalence (2008-2017) increased for AD (318 to 354), and MCI (13 to 99). In MA (2016) epidemiological estimates were consistent with FFS. In 2017, older age, female sex and the Northeastern region were consistently associated with higher AD/MCI prevalence among FFS beneficiaries. In FFS, AD/MCI diagnostic prevalence increased over 10 years, especially for MCI; prevalence estimates in MA (2016) were comparable. Diagnostic prevalence in 2016 (FFS + MA) was 3.4% for AD and 0.85% for MCI. Our findings address the reality of Alzheimer's disease in clinical practice in the United States that is confronted by healthcare professionals, payors, healthcare decision-makers, patients, and caregivers, and may offer a realistic gauge for patient triage for treatment, healthcare resource allocation, and health-systems' operational prioritization. With the availability of anti-amyloid treatments, we anticipate that the population with diagnosed MCI/AD within the Medicare database may rise over time; therefore, periodic updates of incidence/prevalence estimates may provide support for timely healthcare decision-making.

Key findings

In FFS, AD incidence (2008-2018) decreased (138 to 104); MCI incidence increased (8 to 47), but the sum (MCI + AD) was relatively stable (146 to 151).
Prevalence (2008-2017) increased for AD (318 to 354), and MCI (13 to 99).
In MA (2016) epidemiological estimates were consistent with FFS.
In 2017, older age, female sex and the Northeastern region were consistently associated with higher AD/MCI prevalence among FFS beneficiaries.
In FFS, AD/MCI diagnostic prevalence increased over 10 years, especially for MCI; prevalence estimates in MA (2016) were comparable.

Why it matters

This study described how often Alzheimer's disease and mild cognitive impairment were diagnosed in Medicare beneficiaries, finding that AD incidence decreased while MCI incidence increased and overall diagnostic prevalence rose over 10 years. It provides estimates of diagnosed disease in the population but does not test any treatment, cure, or prevention for Alzheimer's disease.

Study details

Effect size3.4%; 0.85%
Evidence strengthLow

How this study scored 41/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Neurology and Therapy)
Journal's citation record	0 / 4	Neurology and Therapy: journal h-index 57 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2024 — within 3 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	2 / 7	Cited 6 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	1.5 citations a year over 4 year(s) since 2024
Impact for its field and year	2 / 6	Cited 1.6× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 6 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author Lawrence S. Honig: h-index 103 (OpenAlex, whole career)
Institution's track record	2 / 3	Columbia University: institution h-index 1,824 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 3 institution(s) in 2 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 39699743)
Free to read	2 / 2	Free to read
Total	41 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

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Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.

APA 7th

Zhang, H., Monfared, A. A. T., Zhang, Q., & Honig, L. S. (2024). Incidence and Prevalence of Alzheimer’s Disease in Medicare Beneficiaries. Neurology and Therapy. https://doi.org/10.1007/s40120-024-00695-6

Vancouver

Zhang H, Monfared AAT, Zhang Q, Honig LS. Incidence and Prevalence of Alzheimer’s Disease in Medicare Beneficiaries. Neurology and Therapy. 2024. doi:10.1007/s40120-024-00695-6. PMID: 39699743.

BibTeX

@article{zhang2024-39699743,
  author  = {Zhang, Haixin and Monfared, Amir Abbas Tahami and Zhang, Quanwu and Honig, Lawrence S.},
  title   = {{Incidence and Prevalence of Alzheimer’s Disease in Medicare Beneficiaries}},
  journal = {Neurology and Therapy},
  year    = {2024},
  doi     = {10.1007/s40120-024-00695-6},
  pmid    = {39699743},
  url     = {https://doi.org/10.1007/s40120-024-00695-6}
}

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