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38/100

✓ Peer-reviewed alzhub usefulness score 38 out of 100. Mild cognitive impairment

Topic: Risk, prevention and care in population studies

Plain-language summary

The DMN is the highest coverage of brain network regarding changes in local brain activity in patients with MCI. And the MCI group showed significant aberrant lateralization of the ALFF value. The current results of our study has confirmed the hypothesis of cerebral functional impairment and compensation, and suggests that functional changes in the brain regions with reduced values of the ALFF occurred earlier than those with increased values. In a word, it suggested that the aberrant spontaneous brain activity in the DMN might be a specific imaging marker for improving MCI diagnoses.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Shao, Y., Li, Y., Wang, Z., Zeng, Y., Yang, Y., Wang, Y., et al. (2025). Lateralization of the Aberrant Amplitude of Low-Frequency Fluctuation within the Default Mode Network in Patients with Mild Cognitive Impairment. Academic Radiology. https://doi.org/10.1016/j.acra.2024.12.073

Vancouver

Shao Y, Li Y, Wang Z, Zeng Y, Yang Y, Wang Y, et al. Lateralization of the Aberrant Amplitude of Low-Frequency Fluctuation within the Default Mode Network in Patients with Mild Cognitive Impairment. Academic Radiology. 2025. doi:10.1016/j.acra.2024.12.073. PMID: 39818524.

BibTeX

@article{shao2025-39818524,
  author  = {Shao, Yongjia and Li, Yan and Wang, Zijian and Zeng, Yan and Yang, Yuhan and Wang, Yibin and Zong, Genlin and Xi, Qian},
  title   = {{Lateralization of the Aberrant Amplitude of Low-Frequency Fluctuation within the Default Mode Network in Patients with Mild Cognitive Impairment}},
  journal = {Academic Radiology},
  year    = {2025},
  doi     = {10.1016/j.acra.2024.12.073},
  pmid    = {39818524},
  url     = {https://doi.org/10.1016/j.acra.2024.12.073}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

How to read this study

Design: our record does not state a study design, so check the methods section of the original before weighing the result.
Size: the record lists 36 participants. Ask whether that is enough for the question, and who they were.
Effect: the record gives no effect size, so the summary above cannot say how large any difference was.

What the evidence grade means here

This page is graded low. alzhub.org assigns the grade automatically from keywords in the abstract, not from reading the paper. Low means the abstract matched neither pattern. It is the default label, and it does not mean the work is poor; many sound lab and imaging papers land here. It can add at most 5 of the 100 points in the study score, and it is a label about design, not a verdict on whether the findings are true.

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Key findings

The DMN is the highest coverage of brain network regarding changes in local brain activity in patients with MCI.
And the MCI group showed significant aberrant lateralization of the ALFF value.
The current results of our study has confirmed the hypothesis of cerebral functional impairment and compensation, and suggests that functional changes in the brain regions with reduced values of the ALFF occurred earlier than those with increased values.
In a word, it suggested that the aberrant spontaneous brain activity in the DMN might be a specific imaging marker for improving MCI diagnoses.

Why it matters

This study found that people with mild cognitive impairment showed significant aberrant lateralization of spontaneous brain activity within the default mode network. The authors suggest this aberrant activity might be a specific imaging marker for improving mild cognitive impairment diagnoses, not a treatment.

Study details

Participants36
Evidence strengthLow

How this study scored 38/100

Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Academic Radiology)
Journal's citation record	1 / 4	Academic Radiology: journal h-index 128 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	1 / 4	36 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 2 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.7 citations a year over 3 year(s) since 2025
Impact for its field and year	2 / 6	Cited 1.1× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	1 / 4	Last-listed author Qian Xi: h-index 15 (OpenAlex, whole career)
Institution's track record	1 / 3	Fudan University: institution h-index 954 (OpenAlex)
Multicenter collaboration	2 / 3	OpenAlex lists 8 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 39818524)
Free to read	2 / 2	Free to read
Total	38 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

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