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Investigating neuropathological correlates of hyperactive and psychotic symptoms in dementia: a systematic review
Negro G, Rossi M, Imbimbo C, Gatti A, Magi A, Appollonio IM, Costa A, Poloni TE.. Frontiers in dementia, 2025-01-29
Topic: Risk, prevention and care in population studies
This systematic review aims to elucidate the neuropathological basis of the HIDA and psychosis domains, exploring whether distinct proteinopathies and neural circuit dysfunctions are associated with these symptoms. Results From 846 records identified, 37 studies met inclusion criteria. The neuropathological analysis revealed the co-occurrence of multiple proteinopathies, particularly TAUopathy, TDP-43 pathology, and Lewy-related pathology (LRP), with the latter, in association with ADNC, reported in 15 studies. Evidence suggests that TAUopathy and multiple proteinopathies in key brain regions, such as amygdala, are central to the development of these symptoms.
Key findings
- This systematic review aims to elucidate the neuropathological basis of the HIDA and psychosis domains, exploring whether distinct proteinopathies and neural circuit dysfunctions are associated with these symptoms.
- Results From 846 records identified, 37 studies met inclusion criteria.
- The neuropathological analysis revealed the co-occurrence of multiple proteinopathies, particularly TAUopathy, TDP-43 pathology, and Lewy-related pathology (LRP), with the latter, in association with ADNC, reported in 15 studies.
- Evidence suggests that TAUopathy and multiple proteinopathies in key brain regions, such as amygdala, are central to the development of these symptoms.
Why it matters
From 846 records, 37 studies were reviewed to see what brain changes lie behind hyperactive and psychotic symptoms in dementia. Multiple abnormal proteins often occurred together, including tau, TDP-43 and Lewy-related pathology. The evidence suggests that tau and mixed protein build-up in key regions such as the amygdala, an emotion-processing area, are central to the development of these symptoms.
Study details
- Study designsystematic review
- Effect size83.44%; 5.37%; 13.40%
- Evidence strengthHigh
How this study scored 53/100
Published in a peer-reviewed journal, and it is a systematic review of all the studies on the question. Scored zero for sample size and studied in people because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Frontiers in dementia) |
| Journal's citation record | 0 / 4 | Frontiers in Dementia: journal h-index 13 (OpenAlex, 2026-10-29) |
| Study design | 12 / 12 | A systematic review of all the studies on the question |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | A review of other studies — randomisation is not credited here |
| Times cited | 1 / 7 | Cited 3 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 1 / 6 | Cited 0.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Tino Emanuele Poloni: h-index 20 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Pavia: institution h-index 809 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39949536) |
| Free to read | 2 / 2 | Free to read |
| Total | 53 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.3389/frdem.2025.1513644
- PubMed: 39949536
- Original source →
- Free full text: Frontiers in Dementia →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Negro, G., Rossi, M., Imbimbo, C., Gatti, A., Magi, A., Appollonio, I. M., et al. (2025). Investigating neuropathological correlates of hyperactive and psychotic symptoms in dementia: a systematic review. Frontiers in dementia. https://doi.org/10.3389/frdem.2025.1513644
Vancouver
Negro G, Rossi M, Imbimbo C, Gatti A, Magi A, Appollonio IM, et al. Investigating neuropathological correlates of hyperactive and psychotic symptoms in dementia: a systematic review. Frontiers in dementia. 2025. doi:10.3389/frdem.2025.1513644. PMID: 39949536.
BibTeX
@article{negro2025-39949536,
author = {Negro, G. and Rossi, M. and Imbimbo, C. and Gatti, A. and Magi, A. and Appollonio, I. M. and Costa, A. and Poloni, T. E.},
title = {{Investigating neuropathological correlates of hyperactive and psychotic symptoms in dementia: a systematic review}},
journal = {Frontiers in dementia},
year = {2025},
doi = {10.3389/frdem.2025.1513644},
pmid = {39949536},
url = {https://doi.org/10.3389/frdem.2025.1513644}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here. Showing 12 of 20.