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Alzheimer's disease: insights into pathology, molecular mechanisms, and therapy
Zheng Q, Wang X.. Protein & cell, 2025-02-01
Topic: Amyloid, tau and blood-test diagnosis
Alzheimer's disease (AD), the leading cause of dementia, is characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the brain. This condition casts a significant shadow on global health due to its complex and multifactorial nature. In addition to genetic predispositions, the development of AD is influenced by a myriad of risk factors, including aging, systemic inflammation, chronic health conditions, lifestyle, and environmental exposures. Recent advancements in understanding the complex pathophysiology of AD are paving the way for enhanced diagnostic techniques, improved risk assessment, and potentially effective prevention strategies. These discoveries are crucial in the quest to unravel the complexities of AD, offering a beacon of hope for improved management and treatment options for the millions affected by this debilitating disease.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Zheng, Q., & Wang, X. (2025). Alzheimer's disease: insights into pathology, molecular mechanisms, and therapy. Protein & cell. https://doi.org/10.1093/procel/pwae026
Vancouver
Zheng Q, Wang X. Alzheimer's disease: insights into pathology, molecular mechanisms, and therapy. Protein & cell. 2025. doi:10.1093/procel/pwae026. PMID: 38733347.
BibTeX
@article{zheng2025-38733347,
author = {Zheng, Q. and Wang, X.},
title = {{Alzheimer's disease: insights into pathology, molecular mechanisms, and therapy}},
journal = {Protein \& cell},
year = {2025},
doi = {10.1093/procel/pwae026},
pmid = {38733347},
url = {https://doi.org/10.1093/procel/pwae026}
}
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Key findings
- This condition casts a significant shadow on global health due to its complex and multifactorial nature.
Why it matters
This review describes Alzheimer's disease as complex and multifactorial, influenced by genetic predispositions and risk factors including aging, systemic inflammation, chronic health conditions, lifestyle, and environmental exposures. It says recent advances are paving the way for improved diagnosis, risk assessment, and potentially effective prevention strategies, but no specific treatment or cure is reported.
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Study details
- Evidence strengthLow
How this study scored 53/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Protein & cell) |
| Journal's citation record | 1 / 4 | Protein & Cell: journal h-index 131 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 406 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 135.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 6 / 6 | Cited 97.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 6 other studies in this library |
| Still being cited | 4 / 4 | Cited 406 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Xin Wang: h-index 38 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Xiamen University: institution h-index 674 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 38733347) |
| Free to read | 2 / 2 | Free to read |
| Total | 53 / 100 | — |
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