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Evaluation of AccuBrain-based MRI quantitative analysis in diagnosing Alzheimer’s disease and assessing behavioral and psychological symptoms of dementia
Huixian Lu, Caixia Xu, Jiaquan Liang. Aging Clinical and Experimental Research, 2025-04-17
Topic: Amyloid, tau and blood-test diagnosis
AD patients had significantly higher AD-RAI (0.91 ± 0.25) and more pronounced hippocampal atrophy (0.36 ± 0.09) compared to MCI and HC (P 0.9 for distinguishing BPSD from non-BPSD patients. The AccuBrain MRI system demonstrated high sensitivity and diagnostic value in distinguishing AD from MCI and HC, as well as in identifying patients with BPSD. Correlation and ROC analyses support the use of these imaging biomarkers for early diagnosis and personalized treatment strategies in AD.
Key findings
- AD patients had significantly higher AD-RAI (0.91 ± 0.25) and more pronounced hippocampal atrophy (0.36 ± 0.09) compared to MCI and HC (P 0.9 for distinguishing BPSD from non-BPSD patients.
- The AccuBrain MRI system demonstrated high sensitivity and diagnostic value in distinguishing AD from MCI and HC, as well as in identifying patients with BPSD.
- Correlation and ROC analyses support the use of these imaging biomarkers for early diagnosis and personalized treatment strategies in AD.
Why it matters
An MRI-based quantitative analysis system distinguished Alzheimer's disease from mild cognitive impairment and healthy controls and identified behavioral symptoms. This supports diagnosis but does not provide a treatment, cure, or prevention.
New to this subject? Start with our plain-English guide: Getting a diagnosis →
Study details
- Participants40
- Evidence strengthLow
How this study scored 38/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on institution's track record, so that was left out: it earned 37 of the 97 points we could judge it on, which is 38 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Aging Clinical and Experimental Research) |
| Journal's citation record | 1 / 4 | Aging Clinical and Experimental Research: journal h-index 125 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 1 / 4 | 40 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 3 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 1.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Jiaquan Liang: h-index 13 (OpenAlex, whole career) |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 0 institution(s) in 0 countries — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40244500) |
| Free to read | 2 / 2 | Free to read |
| Points | 37 / 97 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 37 of the 97 points we could judge it on is 38 out of 100. |
| Total | 38 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1007/s40520-025-03023-6
- PubMed: 40244500
- Original source →
- Free full text: Aging Clinical and Experimental Research →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Lu, H., Xu, C., & Liang, J. (2025). Evaluation of AccuBrain-based MRI quantitative analysis in diagnosing Alzheimer’s disease and assessing behavioral and psychological symptoms of dementia. Aging Clinical and Experimental Research. https://doi.org/10.1007/s40520-025-03023-6
Vancouver
Lu H, Xu C, Liang J. Evaluation of AccuBrain-based MRI quantitative analysis in diagnosing Alzheimer’s disease and assessing behavioral and psychological symptoms of dementia. Aging Clinical and Experimental Research. 2025. doi:10.1007/s40520-025-03023-6. PMID: 40244500.
BibTeX
@article{lu2025-40244500,
author = {Lu, Huixian and Xu, Caixia and Liang, Jiaquan},
title = {{Evaluation of AccuBrain-based MRI quantitative analysis in diagnosing Alzheimer’s disease and assessing behavioral and psychological symptoms of dementia}},
journal = {Aging Clinical and Experimental Research},
year = {2025},
doi = {10.1007/s40520-025-03023-6},
pmid = {40244500},
url = {https://doi.org/10.1007/s40520-025-03023-6}
}
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