Home › Research › Cognitive tests and assessment
The relationship of 18 F-FDG-PET to other common biomarkers of dementia in a clinical cohort with memory deficits
Katharina Woyk, Niels Hansen, Jens Wiltfang, Claudia Lange, Caroline Bouter. Journal of Alzheimer s Disease Reports, 2025-04-16
Topic: Amyloid, tau and blood-test diagnosis
Background Early biomarker-based diagnosis of Alzheimer's disease (AD) is essential, particularly with the increasing availability of new therapeutic options. However, the relationship between imaging and cerebrospinal fluid (CSF) biomarkers, especially in the context of 18 Fluorine-fluorodeoxyglucose positron emission tomography ( 18 F-FDG-PET), remains insufficiently understood. Objective The aim of this study was the evaluation of the relationship between 18 F-FDG-PET and other common fluid and imaging AD-biomarkers in a clinical cohort of patients with cognitive decline and suspected AD. Methods We included n = 90 patients with cognitive decline and clinically suspected AD that underwent 18 F-FDG-PET imagining at our facility. Clinical and imaging data including patient characteristics, CSF biomarkers, Mini-Mental State Examination (MMSE), 18 F-FDG-PET and 18 F-Florbetaben-PET were retrospectively analyzed. PET images were quantified in several brain regions. Results 18 F-FDG uptake correlated with CSF amyloid-β (Aβ) 40 , Aβ 42 , and the Aβ 42/40 ratio in several brain regions, but not with regional 18 F-Florbetaben uptake. 18 F-FDG uptake inversely correlated with t-tau and p-tau in CSF. Furthermore, a correlation between MMSE and 18 F-FDG uptake was also detected in several brain regions. 18 F-FDG-PET and its combination with CSF markers showed the highest predictive power for disease severity. Conclusions The study highlights the potential of integrating 18 F-FDG-PET with CSF biomarkers to improve the diagnosis, prognosis, and monitoring of AD, emphasizing the complexity and regional specificity of biomarker interactions in neurodegeneration.
Key findings
- Results 18 F-FDG uptake correlated with CSF amyloid-β (Aβ) 40 , Aβ 42 , and the Aβ 42/40 ratio in several brain regions, but not with regional 18 F-Florbetaben uptake. 18 F-FDG uptake inversely correlated with t-tau and p-tau in CSF.
Why it matters
Brain glucose uptake on FDG-PET was related to several fluid and imaging Alzheimer's biomarkers and to cognitive scores in patients with memory problems. This helps clarify how these biomarkers relate to each other, but it does not test any treatment or prevention.
Study details
- Participants90
- Evidence strengthModerate
How this study scored 41/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Alzheimer s Disease Reports) |
| Journal's citation record | 0 / 4 | Journal of Alzheimer s Disease Reports: journal h-index 40 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 1 / 4 | 90 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 3 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 1.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Caroline Bouter: h-index 16 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Göttingen: institution h-index 934 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40290782) |
| Free to read | 2 / 2 | Free to read |
| Total | 41 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1177/25424823251314392
- PubMed: 40290782
- Original source →
- Free full text: Journal of Alzheimer s Disease Reports →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Woyk, K., Hansen, N., Wiltfang, J., Lange, C., & Bouter, C. (2025). The relationship of 18 F-FDG-PET to other common biomarkers of dementia in a clinical cohort with memory deficits. Journal of Alzheimer s Disease Reports. https://doi.org/10.1177/25424823251314392
Vancouver
Woyk K, Hansen N, Wiltfang J, Lange C, Bouter C. The relationship of 18 F-FDG-PET to other common biomarkers of dementia in a clinical cohort with memory deficits. Journal of Alzheimer s Disease Reports. 2025. doi:10.1177/25424823251314392. PMID: 40290782.
BibTeX
@article{woyk2025-40290782,
author = {Woyk, Katharina and Hansen, Niels and Wiltfang, Jens and Lange, Claudia and Bouter, Caroline},
title = {{The relationship of 18 F-FDG-PET to other common biomarkers of dementia in a clinical cohort with memory deficits}},
journal = {Journal of Alzheimer s Disease Reports},
year = {2025},
doi = {10.1177/25424823251314392},
pmid = {40290782},
url = {https://doi.org/10.1177/25424823251314392}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.
Related studies in Cognitive tests and assessment
Also tagged “classification”
835 studies in the library carry the topic tag “classification”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 835 tagged studies.