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39/100

✓ Peer-reviewed alzhub usefulness score 39 out of 100. Getting a diagnosis

Topic: Amyloid, tau and blood-test diagnosis

Abstract This case report explores the therapeutic potential of lymphovenous bypass (LVB) surgery performed at the neck in neurodegenerative diseases, specifically Alzheimer's disease (AD) dementia. The subject is a 58-year-old woman who was previously healthy but began experiencing unexplained memory decline and frequent disorientation in the past 7 years, leading to an AD diagnosis. Despite ongoing pharmaceutical therapy, her symptoms progressed to severe dementia accompanied by behavioral and psychological symptoms of dementia (BPSD). Her Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores were both 0/30, and 18F-AV-45 PET/CT revealed abnormal brain amyloid load. For salvage therapy, she underwent LVBs on her neck bilaterally. Postoperatively, she got better MMSE and MoCA scores with dramatic improvement in communication and activity. 18F-AV-45 PET/CT scans 4 months after surgery indicated a reduction in abnormal brain amyloid deposits. This case report highlights the potential effectiveness of LVB surgery in reducing brain amyloid load and attenuating cognitive impairment and BPSD. Further research with animal experiments and clinical trials is necessary to confirm these findings.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Xie, Q., Pak, C. J., Kwon, J. G., Chao, S., & Hong, J. P. (2025). Potential Role of Lymphovenous Bypass in Mitigating Alzheimer's Disease Dementia. Archives of Plastic Surgery. https://doi.org/10.1055/a-2627-9243

Vancouver

Xie Q, Pak CJ, Kwon JG, Chao S, Hong JP. Potential Role of Lymphovenous Bypass in Mitigating Alzheimer's Disease Dementia. Archives of Plastic Surgery. 2025. doi:10.1055/a-2627-9243. PMID: 40709010.

BibTeX

@article{xie2025-40709010,
  author  = {Xie, Qingping and Pak, Changsik John and Kwon, Jin Geun and Chao, Sung‐Chuan and Hong, Joon Pio},
  title   = {{Potential Role of Lymphovenous Bypass in Mitigating Alzheimer's Disease Dementia}},
  journal = {Archives of Plastic Surgery},
  year    = {2025},
  doi     = {10.1055/a-2627-9243},
  pmid    = {40709010},
  url     = {https://doi.org/10.1055/a-2627-9243}
}

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Key findings

Her Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores were both 0/30, and 18F-AV-45 PET/CT revealed abnormal brain amyloid load.
Further research with animal experiments and clinical trials is necessary to confirm these findings.

Why it matters

This case report describes a single patient with severe Alzheimer's dementia who showed improved cognitive scores and reduced brain amyloid deposits after lymphovenous bypass surgery. The authors state that further research with animal experiments and clinical trials is necessary to confirm these findings.

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Study details

Study designcase report
Evidence strengthLow

How this study scored 39/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Archives of Plastic Surgery)
Journal's citation record	0 / 4	Archives of Plastic Surgery: journal h-index 57 (OpenAlex, 2026-10-29)
Study design	0 / 12	Design recorded as “case report”, which our rubric does not rank (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	2 / 7	Cited 10 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	3.3 citations a year over 3 year(s) since 2025
Impact for its field and year	3 / 6	Cited 6.4× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 10 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Joon Pio Hong: h-index 44 (OpenAlex, whole career)
Institution's track record	1 / 3	National Taiwan University: institution h-index 752 (OpenAlex)
Multicenter collaboration	2 / 3	OpenAlex lists 4 institution(s) in 2 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40709010)
Free to read	2 / 2	Free to read
Total	39 / 100	—

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