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59/100

✓ Peer-reviewed alzhub usefulness score 59 out of 100. Prevention trials

Topic: Risk, prevention and care in population studies

Introduction Growing research suggests that dementia is a complex disorder with multiple risk factors and causes. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) demonstrated that lifestyle interventions could confer cognitive benefits. Inspired by this, the GOIZ-ZAINDU (GZ) feasibility study adapted the FINGER approach to the Basque context. Building upon the GZ study, the CITA GO-ON trial aims to enhance and expand the evidence supporting dementia prevention through a multidomain intervention of risk factor management and resilience promotion. Methods It is a two-year, population-based, randomized controlled trial to prevent cognitive decline in adults aged 60–85 years with Cardiovascular Risk Factors, Aging and Dementia (CAIDE) risk score ≥6, no dementia, and below-than-expected performance on at least one of three cognitive screening tests. Participants are randomized (1:1) to receive either Regular Health Advice (RHA) or a Multidomain Intervention (MD-Int) that encompasses cognitive training, socio-emotional skills, multicomponent physical exercise, nutritional and culinary intervention, and monitoring for cardiovascular risks, pharmacological drug mismanagement, and comorbidities. The primary outcome is the efficacy of the intervention to reduce the risk of cognitive decline measured by the global composite z-score of the modified Neuropsychological Test Battery over two years. The secondary outcomes measure cost-effectiveness, quality of life, and functional abilities. Blood samples and brain imaging will also be collected to evaluate the effects of the intervention on brain structure and plasma biomarkers. Results Recruitment has been completed with 1051 participants selected (mean age (standard deviation, SD) of 69.65 (6.36), 58,50 % female, and mean CAIDE (SD) of 7.62 (1.427). The final participant is expected to complete the last study visit by the autumn of 2026. Discussion The CITA GO-ON Study, as a part of the World-Wide FINGERS network, is designed to validate the efficacy of a multidomain lifestyle intervention for dementia prevention and contribute valuable data to inform public health strategies fostering healthy, active aging.

Key findings

Introduction Growing research suggests that dementia is a complex disorder with multiple risk factors and causes.
The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) demonstrated that lifestyle interventions could confer cognitive benefits.
Results Recruitment has been completed with 1051 participants selected (mean age (standard deviation, SD) of 69.65 (6.36), 58,50 % female, and mean CAIDE (SD) of 7.62 (1.427).

Why it matters

This is a protocol and recruitment report for a two-year randomized controlled trial testing a multidomain lifestyle intervention against regular health advice in 1051 adults aged 60-85 at risk of cognitive decline. No outcome results are reported yet, so it cannot yet say whether the intervention prevents cognitive decline.

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Study details

Study designrandomized controlled trial
Participants1,051
Evidence strengthHigh

How this study scored 59/100

Published in a peer-reviewed journal, and it is a randomised controlled trial. Scored zero for effect reported because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Frontiers in Aging Neuroscience)
Journal's citation record	2 / 4	Frontiers in Aging Neuroscience: journal h-index 174 (OpenAlex, 2026-10-29)
Study design	11 / 12	A randomised controlled trial
Strength of evidence	5 / 5	Rated “high” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	3 / 4	1,051 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	1 / 2	Randomised (as stated in the record)
Times cited	1 / 7	Cited 2 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.7 citations a year over 3 year(s) since 2025
Impact for its field and year	2 / 6	Cited 1.3× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	1 / 6	Cited by 1 other studies in this library
Still being cited	0 / 4	Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Pablo Martínez‐Lage: h-index 45 (OpenAlex, whole career)
Institution's track record	0 / 3	Instituto de Salud Carlos III: institution h-index 649 (OpenAlex)
Multi-centre collaboration	3 / 3	OpenAlex lists 13 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40589624)
Free to read	2 / 2	Free to read
Total	59 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

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APA 7th

Tainta, M., Ecay‐Torres, M., Barandiarán, M., Estanga, A., López, C., Altuna, M., et al. (2025). CITA GO-ON study. A community based multidomain lifestyle intervention to prevent cognitive decline. Protocol design and recruitment process. Frontiers in Aging Neuroscience. https://doi.org/10.3389/fnagi.2025.1539711

Vancouver

Tainta M, Ecay‐Torres M, Barandiarán M, Estanga A, López C, Altuna M, et al. CITA GO-ON study. A community based multidomain lifestyle intervention to prevent cognitive decline. Protocol design and recruitment process. Frontiers in Aging Neuroscience. 2025. doi:10.3389/fnagi.2025.1539711. PMID: 40589624.

BibTeX

@article{tainta2025-40589624,
  author  = {Tainta, Mikel and Ecay‐Torres, Mirian and Barandiarán, Myriam and Estanga, Ainara and López, Carolina and Altuna, Miren and Iriondo, Ane and Saldias, Jon and others},
  title   = {{CITA GO-ON study. A community based multidomain lifestyle intervention to prevent cognitive decline. Protocol design and recruitment process}},
  journal = {Frontiers in Aging Neuroscience},
  year    = {2025},
  doi     = {10.3389/fnagi.2025.1539711},
  pmid    = {40589624},
  url     = {https://doi.org/10.3389/fnagi.2025.1539711}
}

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