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Updates on Tau-Related Drug Targets and Potential Disease-Modifying Therapies for Alzheimer Disease
Anabela Djurovic-Topalovic, Natalie G Horgan, Jessica S Fortin. The American journal of pathology, 2025-06-19
Topic: Disease mechanisms in lab and animal studies
Alzheimer disease (AD) is a chronic, multifactorial neurodegenerative disease affecting a large proportion of the elderly population with detrimental psychological and socioeconomic impacts. This review starts with a brief overview of the molecular aspects of AD. It aims to provide recent updates on several potential protein targets studied as valid therapeutic approaches such as Bassoon protein, triggering receptor expressed on myeloid cells 2 (TREM2), phosphorylated tau (chimeric molecules DEPTAC and PhosTAC), O-GlcNAcase (OGA), and misfolded protein seeds. This review emphasizes the importance of pursuing a multifaceted approach to diversify and synergize the current AD pharmacotherapy.
Key findings
- Alzheimer disease (AD) is a chronic, multifactorial neurodegenerative disease affecting a large proportion of the elderly population with detrimental psychological and socioeconomic impacts.
- This review starts with a brief overview of the molecular aspects of AD.
- It aims to provide recent updates on several potential protein targets studied as valid therapeutic approaches such as Bassoon protein, triggering receptor expressed on myeloid cells 2 (TREM2), phosphorylated tau (chimeric molecules DEPTAC and PhosTAC), O-GlcNAcase (OGA), and misfolded protein seeds.
- This review emphasizes the importance of pursuing a multifaceted approach to diversify and synergize the current AD pharmacotherapy.
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Study details
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 24 of the 56 points we could judge it on, which is 43 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (The American journal of pathology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40543706) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 24 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 24 of the 56 points we could judge it on is 43 out of 100. |
| Total | 43 / 100 | — |
What each of these 20 components measures, and what this score is not →
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
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APA 7th
Djurovic-Topalovic, A., Horgan, N. G., & Fortin, J. S. (2025). Updates on Tau-Related Drug Targets and Potential Disease-Modifying Therapies for Alzheimer Disease. The American journal of pathology. https://doi.org/10.1016/j.ajpath.2025.05.020
Vancouver
Djurovic-Topalovic A, Horgan NG, Fortin JS. Updates on Tau-Related Drug Targets and Potential Disease-Modifying Therapies for Alzheimer Disease. The American journal of pathology. 2025. doi:10.1016/j.ajpath.2025.05.020. PMID: 40543706.
BibTeX
@article{djurovictopalovic2025-40543706,
author = {Djurovic-Topalovic, Anabela and Horgan, Natalie G and Fortin, Jessica S},
title = {{Updates on Tau-Related Drug Targets and Potential Disease-Modifying Therapies for Alzheimer Disease}},
journal = {The American journal of pathology},
year = {2025},
doi = {10.1016/j.ajpath.2025.05.020},
pmid = {40543706},
url = {https://doi.org/10.1016/j.ajpath.2025.05.020}
}
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