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Mechanisms of vitamin d deficiency as a risk factor for post-stroke depression, dementia, delirium, and fatigue: A promising therapeutic modality
Pan Xu, Jingyu Li, Wuying Li, Huameng Huang, Weihua Deng, Xing Li. Journal of Affective Disorders Reports, 2025-07-01
Topic: Risk, prevention and care in population studies
Acute ischemic stroke often results in a multitude of neuropsychiatric complications, including depression, dementia, delirium, and fatigue. Research has demonstrated a positive correlation between lower serum vitamin D levels and an elevated risk of these post-stroke symptoms, albeit the precise underlying mechanisms remain incompletely understood. Existing studies indicate that vitamin D deficiency can impair normal immune function, decrease neurotransmitter synthesis, exacerbate oxidative stress damage, and disrupt calcium ion homeostasis. This review consolidates findings from various studies, highlighting the strong association between vitamin D deficiency and abnormal post-stroke symptoms. Furthermore, it elucidates the pivotal role of vitamin D in modulating inflammatory responses, mitigating oxidative stress, and facilitating neurotransmitter synthesis. Based on these insights, we propose vitamin D as a promising therapeutic target for both preventing and alleviating abnormal post-stroke symptoms.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Xu, P., Li, J., Li, W., Huang, H., Deng, W., & Li, X. (2025). Mechanisms of vitamin d deficiency as a risk factor for post-stroke depression, dementia, delirium, and fatigue: A promising therapeutic modality. Journal of Affective Disorders Reports. https://doi.org/10.1016/j.jadr.2025.100960
Vancouver
Xu P, Li J, Li W, Huang H, Deng W, Li X. Mechanisms of vitamin d deficiency as a risk factor for post-stroke depression, dementia, delirium, and fatigue: A promising therapeutic modality. Journal of Affective Disorders Reports. 2025. doi:10.1016/j.jadr.2025.100960.
BibTeX
@article{xu2025-f21f9e1b,
author = {Xu, Pan and Li, Jingyu and Li, Wuying and Huang, Huameng and Deng, Weihua and Li, Xing},
title = {{Mechanisms of vitamin d deficiency as a risk factor for post-stroke depression, dementia, delirium, and fatigue: A promising therapeutic modality}},
journal = {Journal of Affective Disorders Reports},
year = {2025},
doi = {10.1016/j.jadr.2025.100960},
url = {https://doi.org/10.1016/j.jadr.2025.100960}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Acute ischemic stroke often results in a multitude of neuropsychiatric complications, including depression, dementia, delirium, and fatigue.
- Research has demonstrated a positive correlation between lower serum vitamin D levels and an elevated risk of these post-stroke symptoms, albeit the precise underlying mechanisms remain incompletely understood.
- Existing studies indicate that vitamin D deficiency can impair normal immune function, decrease neurotransmitter synthesis, exacerbate oxidative stress damage, and disrupt calcium ion homeostasis.
Why it matters
This review reports an association between lower vitamin D levels and higher risk of post-stroke symptoms including dementia and delirium, though the exact mechanisms remain incompletely understood. It proposes vitamin D as a potential therapeutic target for preventing and alleviating these post-stroke symptoms.
Study details
- Evidence strengthLow
How this study scored 29/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 28 of the 96 points we could judge it on, which is 29 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Affective Disorders Reports) |
| Journal's citation record | 0 / 4 | Journal of Affective Disorders Reports: journal h-index 38 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 1 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 1 / 6 | Cited 0.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | 0 / 3 | South China University of Technology: institution h-index 608 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 2 / 2 | Free to read |
| Points | 28 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 28 of the 96 points we could judge it on is 29 out of 100. |
| Total | 29 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1016/j.jadr.2025.100960
- Original source →
- Free full text: Journal of Affective Disorders Reports →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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