This page is alzhub.org's plain-English summary of a published study, not the paper itself. It is generated from the record we hold for this study, sourced and linked below — check the original for the full text and methods.

44/100

✓ Peer-reviewed alzhub usefulness score 44 out of 100. Lewy body dementia

Topic: Brain proteins, microglia and lab models

Forty bvFTD patients and 40 HC (56.25% female, mean age of 63.55 years) were involved. A total of 36 plasma differential metabolites were screened out with variable importance in projection (VIP) > 1 and p < 0.05. Differential metabolites distributed in metabolic pathways that regulate inflammation, such as Aminoacyl-tRNA biosynthesis, mTOR signaling and amino acid metabolism. Furthermore, differential metabolites and plasma inflammatory factors are correlated with atrophy and glucose metabolism in certain frontal-temporal brain regions, as well as cognitive function (p < 0.05). Additionally, the interaction between differential metabolites and inflammatory factors is associated with atrophy and glucose metabolism in the entire frontal-temporal brain region, as well as cognitive function (p < 0.05). Under conditions of dysregulation of inflammatory factors such as Interleukin, Interferons, and Tumour necrosis factor, metabolites in Aminoacyl-tRNA biosynthesis, mTOR signaling, and amino acid metabolism have a more pronounced impact on frontotemporal lobar degeneration and cognitive symptoms (p < 0.05). This study shows that bvFTD exhibits peripheral metabolic and inflammatory dysregulation, which are associated with frontotemporal lobar degeneration and clinical symptoms, and the interaction effects of metabolic and inflammatory dysregulation have a greater impact on bvFTD.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Hou, J., Chu, M. K., Chen, Z., Jiang, D., Chen, Y. A., Yue, A., et al. (2025). Interaction of metabolic and inflammatory dysregulation on central degeneration and cognitive function in behavioral variant Frontotemporal dementia. Journal of Neurology. https://doi.org/10.1007/s00415-025-13268-w

Vancouver

Hou J, Chu MK, Chen Z, Jiang D, Chen YA, Yue A, et al. Interaction of metabolic and inflammatory dysregulation on central degeneration and cognitive function in behavioral variant Frontotemporal dementia. Journal of Neurology. 2025. doi:10.1007/s00415-025-13268-w. PMID: 40707828.

BibTeX

@article{hou2025-40707828,
  author  = {Hou, Jia‐Hui and Chu, Min Kyung and Chen, Zhongyun and Jiang, Deming and Chen, Yufei Andy and Yue, Ailing and He, Qianqian and Lu, Hua Rong and others},
  title   = {{Interaction of metabolic and inflammatory dysregulation on central degeneration and cognitive function in behavioral variant Frontotemporal dementia}},
  journal = {Journal of Neurology},
  year    = {2025},
  doi     = {10.1007/s00415-025-13268-w},
  pmid    = {40707828},
  url     = {https://doi.org/10.1007/s00415-025-13268-w}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

Key findings

Forty bvFTD patients and 40 HC (56.25% female, mean age of 63.55 years) were involved.
A total of 36 plasma differential metabolites were screened out with variable importance in projection (VIP) > 1 and p < 0.05.
Differential metabolites distributed in metabolic pathways that regulate inflammation, such as Aminoacyl-tRNA biosynthesis, mTOR signaling and amino acid metabolism.
Furthermore, differential metabolites and plasma inflammatory factors are correlated with atrophy and glucose metabolism in certain frontal-temporal brain regions, as well as cognitive function (p < 0.05).
Additionally, the interaction between differential metabolites and inflammatory factors is associated with atrophy and glucose metabolism in the entire frontal-temporal brain region, as well as cognitive function (p < 0.05).

Why it matters

This study found that behavioral variant frontotemporal dementia exhibits peripheral metabolic and inflammatory dysregulation associated with frontotemporal lobar degeneration and clinical symptoms, and that the interaction of these dysregulations has a greater impact. It does not test any treatment, so it does not show a cure or prevention.

Study details

Participants36
Effect size56.25%
Evidence strengthLow

How this study scored 44/100

Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of Neurology)
Journal's citation record	2 / 4	Journal of Neurology: journal h-index 208 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	1 / 4	36 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	2 / 7	Cited 5 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	1.7 citations a year over 3 year(s) since 2025
Impact for its field and year	3 / 6	Cited 3.2× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 5 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Liyong Wu: h-index 24 (OpenAlex, whole career)
Institution's track record	0 / 3	Capital Medical University: institution h-index 643 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 2 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40707828)
Free to read	2 / 2	Free to read
Total	44 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Studies this one cites

Referenced by this study and also in the alzhub library, so you can read them here.

Related studies in Lewy body dementia

Also tagged “bodies”

1,017 studies in the library carry the topic tag “bodies”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 1,017 tagged studies.

Similar studies

More on Lewy body dementia

See all studies in Lewy body dementia →