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Dementia With Lewy Bodies
Bhavana R. Patel. CONTINUUM Lifelong Learning in Neurology, 2025-08-01
Topic: Risk, prevention and care in population studies
OBJECTIVE: This article reviews the diagnosis of dementia with Lewy bodies, the prodromal phase of dementia with Lewy bodies, and management of the disease. LATEST DEVELOPMENTS: The diagnostic criteria and characterization of syndromes for prodromal dementia with Lewy bodies facilitate earlier recognition of individuals at risk of Lewy body dementia. Earlier diagnosis may prevent iatrogenic complications, guide families to seek appropriate resources, and provide an opportunity for future therapeutic interventions in the clinical prodrome. Advances in biomarkers include the detection of phosphorylated α-synuclein in cutaneous nerve fibers and the CSF α-synuclein seed amplification assay. ESSENTIAL POINTS: Dementia with Lewy bodies is a complex disease that requires an interdisciplinary approach to optimize diagnosis and management. Frequently occurring copathology, most commonly with Alzheimer disease, leads to greater cognitive decline, increased likelihood of admission to a long-term care facility, and a higher risk of mortality. Use of available biomarkers may better guide appropriate diagnosis and management.
Key findings
- Frequently occurring copathology, most commonly with Alzheimer disease, leads to greater cognitive decline, increased likelihood of admission to a long-term care facility, and a higher risk of mortality.
Why it matters
This article reviews the diagnosis, prodromal phase and management of dementia with Lewy bodies, including biomarkers such as phosphorylated α-synuclein in cutaneous nerve fibres and the CSF α-synuclein seed amplification assay. It focuses on earlier diagnosis and management of dementia with Lewy bodies and does not report a treatment, cure or prevention for Alzheimer's disease.
Study details
- Evidence strengthLow
How this study scored 30/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on senior author's track record and institution's track record, so those were left out: it earned 28 of the 93 points we could judge it on, which is 30 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (CONTINUUM Lifelong Learning in Neurology) |
| Journal's citation record | 1 / 4 | CONTINUUM Lifelong Learning in Neurology: journal h-index 79 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 2 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.7 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 1.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 0 institution(s) in 0 countries — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40748123) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 28 / 93 | Scored on 18 of 20 parts. We have no data for the rest, so they are left out: 28 of the 93 points we could judge it on is 30 out of 100. |
| Total | 30 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
May need a subscription OpenAlex found no free copy of the full text (checked 6 Feb 1020), so the publisher may charge for it. The PubMed abstract is free.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Patel, B. R. (2025). Dementia With Lewy Bodies. CONTINUUM Lifelong Learning in Neurology. https://doi.org/10.1212/cont.0000000000001604
Vancouver
Patel BR. Dementia With Lewy Bodies. CONTINUUM Lifelong Learning in Neurology. 2025. doi:10.1212/cont.0000000000001604. PMID: 40748123.
BibTeX
@article{patel2025-40748123,
author = {Patel, Bhavana R.},
title = {{Dementia With Lewy Bodies}},
journal = {CONTINUUM Lifelong Learning in Neurology},
year = {2025},
doi = {10.1212/cont.0000000000001604},
pmid = {40748123},
url = {https://doi.org/10.1212/cont.0000000000001604}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here. Showing 12 of 25.