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Cardiovascular damage, arrhythmogenesis and overlapping Alzheimer and Parkinson's diseases and TDP-43 pathology start in pediatric and young adult urban populations: Magnetic ultrafine particulate matter and industrial particles with motion behavior play a key role
Lilian Calderón-Garcidueñas, Rubén Cejudo, Angélica González-Maciel, Rafael Reynoso-Robles, Andrea Ramos-Morales, Beatríz Pérez-Guillé, Rosa Eugenia Soriano‐Rosales, Ricardo Torres‐Jardón. Environmental Research, 2025-08-11
Topic: Brain proteins, microglia and lab models
Cardiac damage and neurodegeneration simultaneously evolve in children and young adults, exposed to environmental oxidative, magnetic, motion capable, ultrafine particulate matter (UFPM) and industrial nanoparticles (NPs). Particles move in situ when exposed to DC/AC magnetic 30-50 μT fields, and are documented in fetal hearts, brains and placentas. We identify magnetic NPs and measured motion behavior under AC and DC fields in ventricles, septum, atrioventricular (AV) conduction axis, auricles and ventricles, in healthy hearts of 18 Metropolitan Mexico City (MMC) 30.4 ± 9.4y olds with Alzheimer's, Parkinson's and/or TDP-43 neuropathology. Saturation isothermal remanent magnetization (SIRM), capturing magnetic FeNPs ̴ 20 nm, was recorded in all samples. Type 1 motion responses were identified in 19/35 samples under 25 mT with an x-direction 2.9° variation orientation. Movement 4.7 to 13.4° identified Type 2 motion, while ≥90° (Type 3) supported material moving erratically. AV samples exhibited Type 2 motion with high and low coercivity particles: the latter capable of interacting with low magnetic fields and carrying a high arrhythmogenesis risk. UFPM/NPs produce oxidative stress and striking tissue retention and magnetic effects. Superparamagnetic UFPM/NPs 7-25 nm produce magnetic hyperthermia that could be subjected to remote temperature and motion induction through natural and human-made static and alternating, pulsating dynamic electromagnetic fields i.e., power lines, electrical wiring, radiofrequency radiation (wireless telecommunication devices and equipment). Distinctive magnetic behavior and ferrimagnetic/antiferrimagnetic properties could have a critical impact on heart responses to electromagnetic fields. Cardiac and neurotoxic NPs burden are connected. We should focus towards prenatal and paediatric CVD and neurodegenerative diseases' prevention.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Calderón-Garcidueñas, L., Cejudo, R., González-Maciel, A., Reynoso-Robles, R., Ramos-Morales, A., Pérez-Guillé, B., et al. (2025). Cardiovascular damage, arrhythmogenesis and overlapping Alzheimer and Parkinson's diseases and TDP-43 pathology start in pediatric and young adult urban populations: Magnetic ultrafine particulate matter and industrial particles with motion behavior play a key role. Environmental Research. https://doi.org/10.1016/j.envres.2025.122558
Vancouver
Calderón-Garcidueñas L, Cejudo R, González-Maciel A, Reynoso-Robles R, Ramos-Morales A, Pérez-Guillé B, et al. Cardiovascular damage, arrhythmogenesis and overlapping Alzheimer and Parkinson's diseases and TDP-43 pathology start in pediatric and young adult urban populations: Magnetic ultrafine particulate matter and industrial particles with motion behavior play a key role. Environmental Research. 2025. doi:10.1016/j.envres.2025.122558. PMID: 40803397.
BibTeX
@article{calderongarciduenas2025-40803397,
author = {Calderón-Garcidueñas, Lilian and Cejudo, Rubén and González-Maciel, Angélica and Reynoso-Robles, Rafael and Ramos-Morales, Andrea and Pérez-Guillé, Beatríz and Soriano‐Rosales, Rosa Eugenia and Torres‐Jardón, Ricardo},
title = {{Cardiovascular damage, arrhythmogenesis and overlapping Alzheimer and Parkinson's diseases and TDP-43 pathology start in pediatric and young adult urban populations: Magnetic ultrafine particulate matter and industrial particles with motion behavior play a key role}},
journal = {Environmental Research},
year = {2025},
doi = {10.1016/j.envres.2025.122558},
pmid = {40803397},
url = {https://doi.org/10.1016/j.envres.2025.122558}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- UFPM/NPs produce oxidative stress and striking tissue retention and magnetic effects.
- Superparamagnetic UFPM/NPs 7-25 nm produce magnetic hyperthermia that could be subjected to remote temperature and motion induction through natural and human-made static and alternating, pulsating dynamic electromagnetic fields i.e., power lines, electrical wiring, radiofrequency radiation (wireless telecommunication devices and equipment).
- Distinctive magnetic behavior and ferrimagnetic/antiferrimagnetic properties could have a critical impact on heart responses to electromagnetic fields.
- Cardiac and neurotoxic NPs burden are connected.
- We should focus towards prenatal and paediatric CVD and neurodegenerative diseases' prevention.
Why it matters
This study reports magnetic nanoparticles in heart tissue of young urban residents who also had Alzheimer's, Parkinson's, or TDP-43 pathology, and describes how these particles move under magnetic fields. It proposes that exposure to ultrafine particulate matter may contribute to both heart damage and neurodegeneration starting early in life, but does not test whether treating or removing these particles changes disease.
Study details
- Evidence strengthLow
How this study scored 39/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Environmental Research) |
| Journal's citation record | 3 / 4 | Environmental Research: journal h-index 259 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 6 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 2.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 2.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 6 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Ricardo Torres‐Jardón: h-index 45 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Universidad Nacional Autónoma de México: institution h-index 668 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40803397) |
| Free to read | 2 / 2 | Free to read |
| Total | 39 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1016/j.envres.2025.122558
- PubMed: 40803397
- Original source →
- Free full text: Environmental Research →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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Referenced by this study and also in the alzhub library, so you can read them here.
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