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47/100

✓ Peer-reviewed alzhub usefulness score 47 out of 100. Tau biomarkers

Topic: Amyloid, tau and blood-test diagnosis

BackgroundAs the prevalence of Alzheimer disease (AD) rises, early identification of at-risk individuals is essential for effective intervention. Mild behavioral impairment (MBI), which captures emergent and persistent neuropsychiatric symptoms (NPS) in later life, may enhance early detection of AD; however, its associations with 2024 NIA-AA Core 1 biomarkers remain unexplored. We investigated associations between MBI and cerebrospinal fluid (CSF) amyloid β-42 (Aβ42) and phosphorylated tau-181 (p-tau181).MethodBaseline data from 1327 dementia-free Alzheimer's Disease Neuroimaging Initiative (ADNI) participants were analyzed.

Key findings

Mild behavioral impairment (MBI), which captures emergent and persistent neuropsychiatric symptoms (NPS) in later life, may enhance early detection of AD; however, its associations with 2024 NIA-AA Core 1 biomarkers remain unexplored.
We investigated associations between MBI and cerebrospinal fluid (CSF) amyloid β-42 (Aβ42) and phosphorylated tau-181 (p-tau181).MethodBaseline data from 1327 dementia-free Alzheimer's Disease Neuroimaging Initiative (ADNI) participants were analyzed.
Participants were classified as MBI, non-MBI NPS, or no NPS.
Gaussian mixture modeling defined biomarker positivity.

Why it matters

This study looked at whether mild behavioral impairment is linked to Alzheimer's biomarkers in spinal fluid in people without dementia. It is early observational work and does not show that treating these symptoms changes disease course.

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Study details

Effect sizeaOR = 2.26; aOR = 1.72; aOR = 2.33
Evidence strengthLow

How this study scored 47/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of geriatric psychiatry and neurology)
Journal's citation record	1 / 4	Journal of Geriatric Psychiatry and Neurology: journal h-index 105 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	5 / 5	2026 — within 1 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	3 / 3	Effect reported with a statistic (interval, p-value, ratio or similar)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	2 / 7	Cited 9 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	4.5 citations a year over 2 year(s) since 2026
Impact for its field and year	3 / 6	Cited 5.7× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 9 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Zahinoor Ismail: h-index 66 (OpenAlex, whole career)
Institution's track record	2 / 3	University College London: institution h-index 2,029 (OpenAlex)
Multi-centre collaboration	3 / 3	OpenAlex lists 10 institution(s) in 4 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40803669)
Free to read	2 / 2	Free to read
Total	47 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.

APA 7th

Leon, R., Ghahremani, M., Guan, D. X., Smith, E. E., Zetterberg, H., & Ismail, Z. (2026). Enhancing Alzheimer Disease Detection Using Neuropsychiatric Symptoms: The Role of Mild Behavioural Impairment in the Revised NIA-AA Research Framework. Journal of geriatric psychiatry and neurology. https://doi.org/10.1177/08919887251366634

Vancouver

Leon R, Ghahremani M, Guan DX, Smith EE, Zetterberg H, Ismail Z. Enhancing Alzheimer Disease Detection Using Neuropsychiatric Symptoms: The Role of Mild Behavioural Impairment in the Revised NIA-AA Research Framework. Journal of geriatric psychiatry and neurology. 2026. doi:10.1177/08919887251366634. PMID: 40803669.

BibTeX

@article{leon2026-40803669,
  author  = {Leon, R. and Ghahremani, M. and Guan, D. X. and Smith, E. E. and Zetterberg, H. and Ismail, Z.},
  title   = {{Enhancing Alzheimer Disease Detection Using Neuropsychiatric Symptoms: The Role of Mild Behavioural Impairment in the Revised NIA-AA Research Framework}},
  journal = {Journal of geriatric psychiatry and neurology},
  year    = {2026},
  doi     = {10.1177/08919887251366634},
  pmid    = {40803669},
  url     = {https://doi.org/10.1177/08919887251366634}
}

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