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Precision Nutrition for Dementia: Exploring the Potential in Mitigating Dementia Progression
Tara J. Jewell, Michelle Minehan, Jackson Williams, Nathan Martin D'Cunha. Journal of dementia and Alzheimer's disease, 2025-08-14
Topic: Risk, prevention and care in population studies
Precision nutrition is a tailored dietary approach that considers an individual’s genetic and metabolic profile, lifestyle factors, and specific nutritional needs to improve health and potentially modify disease progression. While research is ongoing into precision nutrition approaches for preventing dementia, there is no evidence on its targeted application to slow dementia-related disease progression and mitigate functional and cognitive decline. This narrative review addresses this gap by synthesising evidence on nutrient–gene interactions, genotype, gut microbiome, nutritional status and the interplay between metabolic pathways implicated in neuroinflammation and neurodegeneration to modify disease progression in a protective or therapeutic manner. Understanding and addressing comorbidities that share pathological mechanisms with dementia have the potential to enhance the understanding of precision nutrition to inform more effective, tailored approaches to slow dementia progression. To increase the robustness of precision nutrition trials for people with dementia, further research is needed into biomarker discovery, multi-omics technologies, and increasing mechanistic research to map the precise biological pathways underpinning the interactions between diet, gene expression, and neuroinflammation. Moreover, there is a need to evaluate the feasibility of precision nutrition for people experiencing cognitive impairment. Addressing these gaps will determine if people with dementia can benefit from precision nutrition and, subsequently, improve their quality of life and health outcomes.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Jewell, T. J., Minehan, M., Williams, J., & D'Cunha, N. M. (2025). Precision Nutrition for Dementia: Exploring the Potential in Mitigating Dementia Progression. Journal of dementia and Alzheimer's disease. https://doi.org/10.3390/jdad2030028
Vancouver
Jewell TJ, Minehan M, Williams J, D'Cunha NM. Precision Nutrition for Dementia: Exploring the Potential in Mitigating Dementia Progression. Journal of dementia and Alzheimer's disease. 2025. doi:10.3390/jdad2030028.
BibTeX
@article{jewell2025-41334248,
author = {Jewell, Tara J. and Minehan, Michelle and Williams, Jackson and D'Cunha, Nathan Martin},
title = {{Precision Nutrition for Dementia: Exploring the Potential in Mitigating Dementia Progression}},
journal = {Journal of dementia and Alzheimer's disease},
year = {2025},
doi = {10.3390/jdad2030028},
url = {https://doi.org/10.3390/jdad2030028}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- This narrative review addresses this gap by synthesising evidence on nutrient–gene interactions, genotype, gut microbiome, nutritional status and the interplay between metabolic pathways implicated in neuroinflammation and neurodegeneration to modify disease progression in a protective or therapeutic manner.
- Understanding and addressing comorbidities that share pathological mechanisms with dementia have the potential to enhance the understanding of precision nutrition to inform more effective, tailored approaches to slow dementia progression.
- To increase the robustness of precision nutrition trials for people with dementia, further research is needed into biomarker discovery, multi-omics technologies, and increasing mechanistic research to map the precise biological pathways underpinning the interactions between diet, gene expression, and neuroinflammation.
- Moreover, there is a need to evaluate the feasibility of precision nutrition for people experiencing cognitive impairment.
- Addressing these gaps will determine if people with dementia can benefit from precision nutrition and, subsequently, improve their quality of life and health outcomes.
Why it matters
This narrative review discusses whether tailored nutrition based on genetics, metabolism and the gut microbiome could slow dementia progression. The text states there is no evidence on its targeted application to slow dementia-related progression, so no benefit is established.
Study details
- Study designnarrative review
- Evidence strengthLow
How this study scored 29/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of dementia and Alzheimer's disease) |
| Journal's citation record | 0 / 4 | Journal of dementia and Alzheimer's disease: journal h-index 7 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | Design recorded as “narrative review”, which our rubric does not rank (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 1 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 1 / 6 | Cited 0.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Nathan Martin D'Cunha: h-index 25 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | University of Canberra: institution h-index 279 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 2 / 2 | Free to read |
| Total | 29 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.3390/jdad2030028
- Original source →
- Free full text: Journal of dementia and Alzheimer's disease →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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