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42/100

✓ Peer-reviewed alzhub usefulness score 42 out of 100. Mild cognitive impairment

Topic: Risk, prevention and care in population studies

Fifty-nine patients fulfilled the inclusion criteria. The median age was 82.7 + /-8.7 years, 93 % had amnestic MCI and 45.8 % progressed to dementia (ICD-11 criteria) in two years. P-tau-181 was not prognostic. An RPDPM with the MMSE, clock test, and Lawton's Index could predict progression to dementia with an AUC of 0.945. A combination of the MMSE, clock test, and Lawton's Index in a DPM model predicted progression from MCI to dementia best. P-tau and other blood biomarkers did not predict progression. Our results highlight the strength of clinical variables to predict the progression of MCI.

Key findings

Fifty-nine patients fulfilled the inclusion criteria.
The median age was 82.7 + /-8.7 years, 93 % had amnestic MCI and 45.8 % progressed to dementia (ICD-11 criteria) in two years.
An RPDPM with the MMSE, clock test, and Lawton's Index could predict progression to dementia with an AUC of 0.945.
A combination of the MMSE, clock test, and Lawton's Index in a DPM model predicted progression from MCI to dementia best.
P-tau and other blood biomarkers did not predict progression.

Why it matters

In 59 oldest-old patients with MCI, a model using the MMSE, clock test, and Lawton's Index predicted progression to dementia with an AUC of 0.945, while p-tau-181 and other blood biomarkers did not predict progression. The results highlight the strength of clinical variables for predicting MCI progression, not for treating or preventing it.

Study details

Study designcase-control study
Evidence strengthModerate

How this study scored 42/100

Published in a peer-reviewed journal, and it is a case-control study. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (International Psychogeriatrics)
Journal's citation record	2 / 4	International Psychogeriatrics: journal h-index 161 (OpenAlex, 2026-10-29)
Study design	6 / 12	A case-control study
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 1 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.3 citations a year over 3 year(s) since 2025
Impact for its field and year	1 / 6	Cited 0.6× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Rosario Osta: h-index 41 (OpenAlex, whole career)
Institution's track record	0 / 3	Instituto de Salud Carlos III: institution h-index 649 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 7 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40803947)
Free to read	2 / 2	Free to read
Total	42 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

APA 7th

Molina-Torres, N., Platero, C. A., Pérez-Berasategui, O., Andrés‐Benito, P., Povedano, M., Mesa-Lampré, P., et al. (2025). Clinical parameters predicted the progression to dementia in oldest old patients with mild cognitive impairment (MCI). International Psychogeriatrics. https://doi.org/10.1016/j.inpsyc.2025.100129

Vancouver

Molina-Torres N, Platero CA, Pérez-Berasategui O, Andrés‐Benito P, Povedano M, Mesa-Lampré P, et al. Clinical parameters predicted the progression to dementia in oldest old patients with mild cognitive impairment (MCI). International Psychogeriatrics. 2025. doi:10.1016/j.inpsyc.2025.100129. PMID: 40803947.

BibTeX

@article{molinatorres2025-40803947,
  author  = {Molina-Torres, Nora and Platero, Carlos A. and Pérez-Berasategui, Oscar and Andrés‐Benito, Pol and Povedano, Mónica and Mesa-Lampré, Pilar and Abadía-Morales, María and Calvo, Ana-Cristina and others},
  title   = {{Clinical parameters predicted the progression to dementia in oldest old patients with mild cognitive impairment (MCI)}},
  journal = {International Psychogeriatrics},
  year    = {2025},
  doi     = {10.1016/j.inpsyc.2025.100129},
  pmid    = {40803947},
  url     = {https://doi.org/10.1016/j.inpsyc.2025.100129}
}

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