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The Relationship Between Brainstem Structural Anatomical Parameters And Cognitive Function Impairment Based On The Indonesian Version Of Montreal Cognitive Assessment Score In Clinical Dementia Patients
Ivola Lita Widodo, Firman Parulian Sitanggang, I Made Dwijaputra Ayusta, I Wayan Gede Artawan Eka Putra. Eduvest - Journal Of Universal Studies, 2025-08-13
Topic: Risk, prevention and care in population studies
Dementia is a neurodegenerative disorder characterized by a significant decline in cognitive function. Some studies suggest that structural changes in the brainstem can contribute to cognitive impairment. However, the relationship between the structural anatomical parameters of the brainstem and cognitive function impairment based on the Indonesian version of the Montreal Cognitive Assessment (MoCA) Score in patients with clinical dementia is still not widely studied. This study is an analytical observational study involving 65 patients with clinical dementia who underwent a head MRI examination at Ngoerah Hospital, Denpasar, Bali. The analyzed brainstem structural anatomical parameters included the diameter of the midbrain anteroposterior (AP), midbrain-to-pons ratio, superior cerebellar peduncle (SCP) width, middle cerebellar peduncle (MCP) width, and interpeduncular angle. The relationship between these parameters and cognitive function was measured using the MoCA-Ina score and analyzed by correlation and logistic regression tests. The average diameter of the AP midbrain was 11.1 cm (± 1.63 cm), the median midbrain-to-pons ratio was 0.19, and the median width of SCP and MCP was 1.8 cm and 7.9 cm, respectively. The results of the analysis showed that there was a sufficient positive relationship between the diameter of the AP midbrain and the midbrain-to-pons ratio (r = 0.329, p < 0.001) and between the width of SCP and MCP and the midbrain-to-pons ratio (r = 0.432 and 0.279, p < 0.001). The midbrain-to-pons ratio and MCP width were significantly related to the MoCA-Ina score (r = 0.265 and 0.447, p < 0.001).
Key findings
- Dementia is a neurodegenerative disorder characterized by a significant decline in cognitive function.
- Some studies suggest that structural changes in the brainstem can contribute to cognitive impairment.
- The results of the analysis showed that there was a sufficient positive relationship between the diameter of the AP midbrain and the midbrain-to-pons ratio (r = 0.329, p < 0.001) and between the width of SCP and MCP and the midbrain-to-pons ratio (r = 0.432 and 0.279, p < 0.001).
- The midbrain-to-pons ratio and MCP width were significantly related to the MoCA-Ina score (r = 0.265 and 0.447, p < 0.001).
Why it matters
This study found relationships between brainstem structural parameters and cognitive impairment in clinical dementia patients. However, it is an observational study and does not establish whether these structural changes cause dementia or can be used to treat or prevent it.
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Study details
- Participants65
- Evidence strengthLow
How this study scored 34/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Eduvest - Journal Of Universal Studies) |
| Journal's citation record | 0 / 4 | Eduvest - Journal Of Universal Studies: journal h-index 11 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 1 / 4 | 65 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 2 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.7 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 1.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 0 / 4 | Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author I Wayan Gede Artawan Eka Putra: h-index 9 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Udayana University: institution h-index 125 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 2 / 2 | Free to read |
| Total | 34 / 100 | — |
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Read the original
- DOI: 10.59188/eduvest.v5i8.52021
- Original source →
- Free full text: Eduvest - Journal Of Universal Studies →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Widodo, I. L., Sitanggang, F. P., Ayusta, I. M. D., & Putra, I. W. G. A. E. (2025). The Relationship Between Brainstem Structural Anatomical Parameters And Cognitive Function Impairment Based On The Indonesian Version Of Montreal Cognitive Assessment Score In Clinical Dementia Patients. Eduvest - Journal Of Universal Studies. https://doi.org/10.59188/eduvest.v5i8.52021
Vancouver
Widodo IL, Sitanggang FP, Ayusta IMD, Putra IWGAE. The Relationship Between Brainstem Structural Anatomical Parameters And Cognitive Function Impairment Based On The Indonesian Version Of Montreal Cognitive Assessment Score In Clinical Dementia Patients. Eduvest - Journal Of Universal Studies. 2025. doi:10.59188/eduvest.v5i8.52021.
BibTeX
@article{widodo2025-3dfdbd37,
author = {Widodo, Ivola Lita and Sitanggang, Firman Parulian and Ayusta, I Made Dwijaputra and Putra, I Wayan Gede Artawan Eka},
title = {{The Relationship Between Brainstem Structural Anatomical Parameters And Cognitive Function Impairment Based On The Indonesian Version Of Montreal Cognitive Assessment Score In Clinical Dementia Patients}},
journal = {Eduvest - Journal Of Universal Studies},
year = {2025},
doi = {10.59188/eduvest.v5i8.52021},
url = {https://doi.org/10.59188/eduvest.v5i8.52021}
}
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