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Revised Diagnostic Criteria for Vascular Cognitive Impairment and Dementia—The VasCog-2-WSO Criteria
Perminder Singh Sachdev, Adam C. Bentvelzen, Nicole A. Kochan, Jiyang Jiang, Satoshi Hosoki, Rebecca Koncz, Russell Jude Chander, Danit Saks et al.. JAMA Neurology, 2025-09-16
Topic: Risk, prevention and care in population studies
Three survey rounds included 49 to 54 participants that agreed on VasCog-2 diagnostic criteria for preclinical, mild, and major dementia levels of vascular cognitive impairment (under the overarching term VCID). Research guidelines, including the use of novel neuroimaging and fluid biomarkers, were also agreed on. The World Stroke Organization (WSO) endorsed the criteria, hence named VasCog-2-WSO. Conclusions and Relevance: The VasCog-2-WSO criteria update the VasCog criteria for the diagnosis of VCID, providing operationalization and additional guidance on potential neuroimaging and fluid biomarkers. VasCog-2-WSO should provide an international standard for VCID diagnosis, facilitating diagnostic consistency among clinicians and researchers.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Sachdev, P. S., Bentvelzen, A. C., Kochan, N. A., Jiang, J., Hosoki, S., Koncz, R., et al. (2025). Revised Diagnostic Criteria for Vascular Cognitive Impairment and Dementia—The VasCog-2-WSO Criteria. JAMA Neurology. https://doi.org/10.1001/jamaneurol.2025.3242
Vancouver
Sachdev PS, Bentvelzen AC, Kochan NA, Jiang J, Hosoki S, Koncz R, et al. Revised Diagnostic Criteria for Vascular Cognitive Impairment and Dementia—The VasCog-2-WSO Criteria. JAMA Neurology. 2025. doi:10.1001/jamaneurol.2025.3242. PMID: 40955506.
BibTeX
@article{sachdev2025-40955506,
author = {Sachdev, Perminder Singh and Bentvelzen, Adam C. and Kochan, Nicole A. and Jiang, Jiyang and Hosoki, Satoshi and Koncz, Rebecca and Chander, Russell Jude and Saks, Danit and others},
title = {{Revised Diagnostic Criteria for Vascular Cognitive Impairment and Dementia—The VasCog-2-WSO Criteria}},
journal = {JAMA Neurology},
year = {2025},
doi = {10.1001/jamaneurol.2025.3242},
pmid = {40955506},
url = {https://doi.org/10.1001/jamaneurol.2025.3242}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Three survey rounds included 49 to 54 participants that agreed on VasCog-2 diagnostic criteria for preclinical, mild, and major dementia levels of vascular cognitive impairment (under the overarching term VCID).
- Research guidelines, including the use of novel neuroimaging and fluid biomarkers, were also agreed on.
- The World Stroke Organization (WSO) endorsed the criteria, hence named VasCog-2-WSO.
- Conclusions and Relevance: The VasCog-2-WSO criteria update the VasCog criteria for the diagnosis of VCID, providing operationalization and additional guidance on potential neuroimaging and fluid biomarkers.
- VasCog-2-WSO should provide an international standard for VCID diagnosis, facilitating diagnostic consistency among clinicians and researchers.
Why it matters
This paper presents updated international diagnostic criteria for vascular cognitive impairment and dementia, agreed on by experts and endorsed by the World Stroke Organization. It is about improving diagnosis and consistency, not about treating, curing, or preventing Alzheimer's disease.
Study details
- Participants49
- Evidence strengthLow
How this study scored 61/100
Published in a leading specialty journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 59 of the 96 points we could judge it on, which is 61 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (JAMA Neurology) |
| Journal's citation record | 2 / 4 | JAMA Neurology: journal h-index 235 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 1 / 4 | 49 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 63 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 21.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 6 / 6 | Cited 40.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 5 other studies in this library |
| Still being cited | 3 / 4 | Cited 63 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 75 institution(s) in 19 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40955506) |
| Free to read | 2 / 2 | Free to read |
| Points | 59 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 59 of the 96 points we could judge it on is 61 out of 100. |
| Total | 61 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1001/jamaneurol.2025.3242
- PubMed: 40955506
- Original source →
- Free full text: Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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