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Proteostasis and Neuroinflammation in Alzheimer’s Disease
Augustina Potokiri, Hongmin Wang. Journal of Integrative Neuroscience, 2025-09-18
Topic: Amyloid, tau and blood-test diagnosis
Alzheimer's disease (AD) is the most common cause of dementia in older adults, marked by a gradual and irreversible deterioration of cognitive abilities, including memory and thinking skills. AD is highly heterogeneous, with variations in amyloid and tau pathology, symptoms, proteostasis, neuroinflammation, and genetics. Dysregulated proteostasis and neuroinflammation, though usually protective, contribute significantly to disease progression. Proteostasis refers to the network that maintains the integrity of both intracellular and extracellular proteins, while neuroinflammation is the biological response to harmful stimuli. Proteostasis stress can activate immune responses and cause excessive inflammation, while impaired microglia and astrocyte function can further disrupt proteostasis and worsen disease progression. While numerous reviews on AD exist, this review focuses on the complex interplay between proteostasis and neuroinflammation in AD and their integral roles in disease pathology. Additionally, we will explore current and promising therapeutics targeting these processes, potential biomarkers, and the clinical trials conducted over the past 5 years, particularly those that address neuroinflammation and proteostasis, as identified through a PubMed search.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Potokiri, A., & Wang, H. (2025). Proteostasis and Neuroinflammation in Alzheimer’s Disease. Journal of Integrative Neuroscience. https://doi.org/10.31083/jin39826
Vancouver
Potokiri A, Wang H. Proteostasis and Neuroinflammation in Alzheimer’s Disease. Journal of Integrative Neuroscience. 2025. doi:10.31083/jin39826. PMID: 41074409.
BibTeX
@article{potokiri2025-41074409,
author = {Potokiri, Augustina and Wang, Hongmin},
title = {{Proteostasis and Neuroinflammation in Alzheimer’s Disease}},
journal = {Journal of Integrative Neuroscience},
year = {2025},
doi = {10.31083/jin39826},
pmid = {41074409},
url = {https://doi.org/10.31083/jin39826}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Dysregulated proteostasis and neuroinflammation, though usually protective, contribute significantly to disease progression.
Why it matters
This review focuses on how the systems that maintain protein integrity and the brain's inflammatory response interact in Alzheimer's disease, and on treatments and biomarkers being studied for these processes. It summarizes existing research rather than reporting a new treatment that works.
Study details
- Evidence strengthLow
How this study scored 37/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Integrative Neuroscience) |
| Journal's citation record | 0 / 4 | Journal of Integrative Neuroscience: journal h-index 53 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 9 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 3.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 3 / 6 | Cited 4.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 9 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Hongmin Wang: h-index 32 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Texas Tech University: institution h-index 686 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41074409) |
| Free to read | 2 / 2 | Free to read |
| Total | 37 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.31083/jin39826
- PubMed: 41074409
- Original source →
- Free full text: Journal of Integrative Neuroscience →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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