Home › Research › Risk factors
Sleep Disorders in Neurodegenerative Diseases with Dementia: A Comprehensive Review
Natalia Siwecka, Michał Golberg, Dominika Świerczewska, Beata Filipek, Karolina Pendrasik, Adrianna Bączek-Grzegorzewska, Mariusz Stasiołek, Mariola Matysiak. Journal of Clinical Medicine, 2025-10-09
Topic: Risk, prevention and care in population studies
Dementia is a growing problem of global relevance, currently affecting over 55 million people worldwide. The number of new dementia cases is still increasing, primarily due to the aging of society. Dementia is defined as a substantial decline in cognitive function, and it is inherently associated with neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, dementia with Lewy bodies, frontotemporal dementia, and vascular dementia. Of note, most patients suffering from neurodegenerative conditions, in addition to cognitive impairment, often experience various types of sleep disorders, including insomnia, rapid eye movement sleep behavior disorder, sleep-disordered breathing, and circadian rhythm disturbances. There is increasing evidence of a bidirectional interaction between sleep disturbances and mental health. Disrupted sleep may directly aggravate neuropsychiatric symptoms, like depression, anxiety, agitation, and hallucinations, and conversely, such symptoms can make sleeping more difficult. This creates a feedback loop that inevitably leads to disease progression and deterioration in quality of life. In this review, we provide an up-to-date overview of the nature and mechanisms behind sleep disorders in major neurodegenerative diseases, summarize treatment strategies for handling sleep disturbances, and discuss the clinical relevance of sleep-mental health interactions in the context of neurodegeneration-associated dementia. Neurodegeneration is a complex problem on the border between neurology and psychiatry, and it poses a challenge to the healthcare system, as it requires multidisciplinary approaches for optimal management. Understanding the connection between sleep and neuropsychiatric symptoms offers further opportunities for better symptom control, improved quality of life, and slower cognitive decline.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Siwecka, N., Golberg, M., Świerczewska, D., Filipek, B., Pendrasik, K., Bączek-Grzegorzewska, A., et al. (2025). Sleep Disorders in Neurodegenerative Diseases with Dementia: A Comprehensive Review. Journal of Clinical Medicine. https://doi.org/10.3390/jcm14197119
Vancouver
Siwecka N, Golberg M, Świerczewska D, Filipek B, Pendrasik K, Bączek-Grzegorzewska A, et al. Sleep Disorders in Neurodegenerative Diseases with Dementia: A Comprehensive Review. Journal of Clinical Medicine. 2025. doi:10.3390/jcm14197119. PMID: 41096196.
BibTeX
@article{siwecka2025-41096196,
author = {Siwecka, Natalia and Golberg, Michał and Świerczewska, Dominika and Filipek, Beata and Pendrasik, Karolina and Bączek-Grzegorzewska, Adrianna and Stasiołek, Mariusz and Matysiak, Mariola},
title = {{Sleep Disorders in Neurodegenerative Diseases with Dementia: A Comprehensive Review}},
journal = {Journal of Clinical Medicine},
year = {2025},
doi = {10.3390/jcm14197119},
pmid = {41096196},
url = {https://doi.org/10.3390/jcm14197119}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Dementia is defined as a substantial decline in cognitive function, and it is inherently associated with neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, dementia with Lewy bodies, frontotemporal dementia, and vascular dementia.
Why it matters
This review describes the types of sleep disorders seen in neurodegenerative diseases including Alzheimer's disease, and notes a bidirectional relationship in which disrupted sleep can worsen neuropsychiatric symptoms and vice versa. It summarizes treatment strategies for sleep disturbances but does not report that treating sleep disorders cures or prevents Alzheimer's disease.
New to this subject? Start with our plain-English guide: Risk factors, ranked →
Study details
- Evidence strengthLow
How this study scored 41/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Clinical Medicine) |
| Journal's citation record | 2 / 4 | Journal of Clinical Medicine: journal h-index 188 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 3 / 7 | Cited 15 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 5.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 4 / 6 | Cited 15.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 2 / 4 | Cited 15 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Mariola Matysiak: h-index 17 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Medical University of Warsaw: institution h-index 348 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41096196) |
| Free to read | 2 / 2 | Free to read |
| Total | 41 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.3390/jcm14197119
- PubMed: 41096196
- Original source →
- Free full text: Journal of Clinical Medicine →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Related
Studies in the library that share something with this one. The line above each title says what.
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here. Showing 12 of 16.
Related studies in Risk factors
Also tagged “lewy”
1,017 studies in the library carry the topic tag “lewy”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 1,017 tagged studies.