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[Alzheimer-type dementia and Down syndrome]
Johannsen P, Mai J.. Ugeskrift for laeger, 1995-02-01
Topic: Amyloid, tau and blood-test diagnosis
Dementia is seen earlier and more often in patients with Down syndrome (DS) than in the general population. Patients with DS develop neuropathological changes similar to the changes seen in dementia of Alzheimer's type (DAT). The literature concerning DAT in DS is reviewed. The clinical course and differential diagnoses are discussed. Before the diagnosis of DAT is made, treatable causes of dementia should be excluded.
Key findings
- Dementia is seen earlier and more often in patients with Down syndrome (DS) than in the general population.
- Patients with DS develop neuropathological changes similar to the changes seen in dementia of Alzheimer's type (DAT).
- The literature concerning DAT in DS is reviewed.
- The clinical course and differential diagnoses are discussed.
- Before the diagnosis of DAT is made, treatable causes of dementia should be excluded.
Why it matters
This review notes that dementia appears earlier and more often in people with Down syndrome, who develop brain changes similar to Alzheimer's type. It states that treatable causes of dementia should be ruled out before diagnosing Alzheimer's, but reports no treatment or cure.
Study details
- Evidence strengthLow
How this study scored 26/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, impact for its field and year and senior author's track record, so those were left out: it earned 22 of the 86 points we could judge it on, which is 26 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Ugeskrift for laeger) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1995 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 1 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.0 citations a year over 33 year(s) since 1995 |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | 0 / 3 | Aarhus Municipality: institution h-index 187 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 7879299) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 22 / 86 | Scored on 17 of 20 parts. We have no data for the rest, so they are left out: 22 of the 86 points we could judge it on is 26 out of 100. |
| Total | 26 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. This record has no DOI, so the citation leaves it out. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Johannsen, P., & Mai, J. (1995). [Alzheimer-type dementia and Down syndrome]. Ugeskrift for laeger.
Vancouver
Johannsen P, Mai J. [Alzheimer-type dementia and Down syndrome]. Ugeskrift for laeger. 1995. PMID: 7879299.
BibTeX
@article{johannsen1995-7879299,
author = {Johannsen, P. and Mai, J.},
title = {{[Alzheimer-type dementia and Down syndrome]}},
journal = {Ugeskrift for laeger},
year = {1995},
pmid = {7879299}
}
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