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Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment
Clifford R. Jack, Ronald Petersen, Yun Xu, Peter C. O’Brien, Glenn E. Smith, Robert J. Ivnik, Bradley F. Boeve, Stephen C. Waring et al.. Neurology, 1999-04-01
Topic: Risk, prevention and care in population studies
During the period of longitudinal observation, which averaged 32.6 months, 27 of the 80 MCI patients became demented. Hippocampal atrophy at baseline was associated with crossover from MCI to AD (relative risk [RR], 0.69, p = 0.015). When hippocampal volume was entered into bivariate models-using age, postmenopausal estrogen replacement, standard neuropsychological tests, apolipoprotein E (APOE) genotype, history of ischemic heart disease, and hypertension-the RRs were not substantially different from that found univariately, and the associations between hippocampal volume and crossover remained significant. In older patients with MCI, hippocampal atrophy determined by premorbid MRI-based volume measurements is predictive of subsequent conversion to AD.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Jack, C. R., Petersen, R., Xu, Y., O’Brien, P. C., Smith, G. E., Ivnik, R. J., et al. (1999). Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment. Neurology. https://doi.org/10.1212/wnl.52.7.1397
Vancouver
Jack CR, Petersen R, Xu Y, O’Brien PC, Smith GE, Ivnik RJ, et al. Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment. Neurology. 1999. doi:10.1212/wnl.52.7.1397. PMID: 10227624.
BibTeX
@article{jack1999-10227624,
author = {Jack, Clifford R. and Petersen, Ronald and Xu, Yun and O’Brien, Peter C. and Smith, Glenn E. and Ivnik, Robert J. and Boeve, Bradley F. and Waring, Stephen C. and others},
title = {{Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment}},
journal = {Neurology},
year = {1999},
doi = {10.1212/wnl.52.7.1397},
pmid = {10227624},
url = {https://doi.org/10.1212/wnl.52.7.1397}
}
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Key findings
- During the period of longitudinal observation, which averaged 32.6 months, 27 of the 80 MCI patients became demented.
- Hippocampal atrophy at baseline was associated with crossover from MCI to AD (relative risk [RR], 0.69, p = 0.015).
- When hippocampal volume was entered into bivariate models-using age, postmenopausal estrogen replacement, standard neuropsychological tests, apolipoprotein E (APOE) genotype, history of ischemic heart disease, and hypertension-the RRs were not substantially different from that found univariately, and the associations between hippocampal volume and crossover remained significant.
- In older patients with MCI, hippocampal atrophy determined by premorbid MRI-based volume measurements is predictive of subsequent conversion to AD.
Why it matters
In this longitudinal study, hippocampal atrophy at baseline was associated with progression from mild cognitive impairment to Alzheimer's disease over an average of 32.6 months. It suggests MRI-based hippocampal volume measurement may help predict conversion to Alzheimer's disease in older patients with mild cognitive impairment.
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Study details
- Study designlongitudinal study
- Evidence strengthModerate
How this study scored 66/100
Published in a leading specialty journal, and it is a longitudinal study following the same people over time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1999 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 7 / 7 | Cited 1,413 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 48.7 citations a year over 29 year(s) since 1999 |
| Impact for its field and year | 5 / 6 | Cited 27.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 5 / 6 | Cited by 147 other studies in this library |
| Still being cited | 3 / 4 | Cited 70 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author E. Kokmen: h-index 48 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Mayo Clinic: institution h-index 1,606 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 10227624) |
| Free to read | 2 / 2 | Free to read |
| Total | 66 / 100 | — |
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