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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 25,776–25,800 of 27,380 studies, newest first · page 1032 of 1096.

April 1999 7

  1. 1999-04-01

    Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein

    ✓ Peer-reviewed Risk genes beyond APOE Nature structural biology

    Key finding: A proteolytic-breakdown product of APP, called beta-amyloid, is a major component of the diffuse and fibrillar deposits found in Alzheimer diseased brains. +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 1999-04-01

    Cerebrospinal fluid A beta42 is increased early in sporadic Alzheimer's disease and declines with disease progression

    ✓ Peer-reviewed Mild cognitive impairment Annals of neurology

    Key finding: We found that A beta42 is strongly elevated in early and mid stages of AD, and thereafter it declines with disease progression. +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 1999-04-01

    Incidence and distribution of parkinsonism in Olmsted County, Minnesota, 1976-1990

    ✓ Peer-reviewed How common it is Neurology

    Key finding: Parkinsonism is a common disease among the elderly; its incidence increases steeply with advancing age and is consistently higher in men.

    Full summary, score breakdown and related studies → Original source

  4. 1999-04-01

    Prevalence and impact of caregiving: a detailed comparison between dementia and nondementia caregivers

    ✓ Peer-reviewed Caregiving The Gerontologist

    Key finding: Not only do dementia caregivers spend significantly more hours per week providing care than nondementia caregivers, they also report greater impacts in terms of employment complications, caregiver strain, mental and physical health problems, time for leisure and other family members, and family conflict.

    Full summary, score breakdown and related studies → Original source

  5. 1999-04-01

    Alzheimer neuropathologic alterations in aged cognitively normal subjects

    ✓ Peer-reviewed Getting a diagnosis Journal of neuropathology and experimental neurology

    Key finding: The histopathologic changes distinguishing early Alzheimer disease (AD) from normal or pathologic aging are not clearly defined. +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 1999-04-01

    The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer's disease

    ✓ Peer-reviewed Getting a diagnosis Neurology

    Key finding: The relationship between NFD and Alzheimer-type dementia, and the criteria for a biochemical diagnosis of AD, are documented, and an association between AD and the extent of NFD in defined brain areas is shown.

    Full summary, score breakdown and related studies → Original source

  7. 1999-04-01

    Differential effects of apolipoprotein E isoforms on metal-induced aggregation of A beta using physiological concentrations

    ✓ Peer-reviewed Genetics Biochemistry

    Key finding: Consistent with the increased risk for AD associated with the epsilon 4 allele of APOE, metal-induced aggregation of A beta was highest for both zinc and copper in the presence of apolipoprotein E4.

    Full summary, score breakdown and related studies → Original source

March 1999 18

  1. 1999-03-15

    RNA Oxidation Is a Prominent Feature of Vulnerable Neurons in Alzheimer’s Disease

    ✓ Peer-reviewed Disease mechanisms Journal of Neuroscience

    Key finding: Relative density measurement showed that there was a significant increase (p < 0.0001) in 8OHdG and 8OHG immunoreactivity with 1F7 in cases of AD (n = 22) as compared with senile (n = 13), presenile (n = 10), or young controls (n = 4).

    Full summary, score breakdown and related studies → Original source

  2. 1999-03-01

    Useful services for families: research findings and directions

    ✓ Peer-reviewed Costs and economics International Journal of Geriatric Psychiatry

    Key finding: There are surprisingly few empirical studies overall and the reported benefits typically are modest. +2 more findings

    Full summary, score breakdown and related studies → Original source

  3. 1999-03-01

    Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain

    ✓ Peer-reviewed Disease mechanisms The Journal of biological chemistry

    Key finding: The cognitive impairment, demonstrated in F1 hybrids of the different APP transgenic lines, was significantly different from nontransgenic littermates as early as 3 months of age. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 1999-03-01

    Attention and executive deficits in Alzheimer's disease. A critical review

    ✓ Peer-reviewed Brain tissue and pathology Brain : a journal of neurology

    Key finding: Current evidence suggests that after an initial amnesic stage in Alzheimer's disease, attention is the first non-memory domain to be affected, before deficits in language and visuospatial functions. +1 more finding

    Full summary, score breakdown and related studies → Original source

  5. 1999-03-01

    Complete sequence of a novel protein containing a femtomolar-activity-dependent neuroprotective peptide

    ✓ Peer-reviewed Disease mechanisms Journal of neurochemistry

    Key finding: Here, the complete coding sequence of a novel protein (828 amino acids, pI 5.99), derived from mouse neuroglial cells, is revealed. +2 more findings

    Full summary, score breakdown and related studies → Original source

  6. 1999-03-01

    Efficacy and safety of rivastigmine in patients with Alzheimer's disease: international randomised controlled trial

    ✓ Peer-reviewed Treatments BMJ (Clinical research ed.)

    Key finding: At the end of the study cognitive function had deteriorated among those in the placebo group. +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 1999-03-01

    Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling

    ✓ Peer-reviewed Drug development Proceedings of the National Academy of Sciences of the United States of America

    Key finding: Studies in Caenorhabditis elegans and in mice indicate that one function of presenilin genes is to facilitate Notch-pathway signaling. +1 more finding

    Full summary, score breakdown and related studies → Original source

  8. 1999-03-01

    Evidence for a physical interaction between presenilin and Notch

    ✓ Peer-reviewed Drug development Proceedings of the National Academy of Sciences of the United States of America

    Key finding: When PS1 was immunoprecipitated from 293 cells that had been metabolically labeled with [35S]methionine and [35S]cysteine, Notch1 was the primary protein detected in PS1 immunoprecipitates, suggesting that this interaction is specific. +1 more finding

    Full summary, score breakdown and related studies → Original source

  9. 1999-03-01

    Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice

    ✓ Peer-reviewed Risk genes beyond APOE Nature neuroscience

    Key finding: These deficits are accompanied by minimal or no loss of presynaptic or postsynaptic elementary structural elements in the hippocampus, suggesting that impairments in functional synaptic plasticity may underlie some of the cognitive deficits in these mice and, possibly, in Alzheimer's patients.

    Full summary, score breakdown and related studies → Original source

  10. 1999-03-01

    Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

    ✓ Peer-reviewed Risk genes beyond APOE Proceedings of the National Academy of Sciences of the United States of America

    Key finding: These results support the view that APP is cleaved both at the cell surface and along the secretory pathway. +1 more finding

    Full summary, score breakdown and related studies → Original source

  11. 1999-03-01

    Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

    ✓ Peer-reviewed Risk genes beyond APOE Proceedings of the National Academy of Sciences of the United States of America

    Key finding: Autosomal dominant forms of familial Alzheimer's disease (FAD) are associated with increased production of the amyloid beta peptide, Abeta42, which is derived from the amyloid protein precursor (APP). +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 1999-03-01

    Effect of literacy on neuropsychological test performance in nondemented, education-matched elders

    ✓ Peer-reviewed Vascular contributions Journal of the International Neuropsychological Society : JINS

    Key finding: MANOVAs revealed a significant overall effect for literacy status (literate vs. illiterate) on neuropsychological test performance when groups were matched on years of education. +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 1999-03-01

    The role of excitotoxicity in neurodegenerative disease: implications for therapy

    ✓ Peer-reviewed Vascular contributions Pharmacology & therapeutics

    Key finding: Several clinical trials have evaluated the potential of antiglutamate drugs to improve outcome following acute ischaemic stroke, but to date, the results of these have been disappointing. +1 more finding

    Full summary, score breakdown and related studies → Original source

  14. 1999-03-01

    Effect of chronic high-dose exogenous cortisol on hippocampal neuronal number in aged nonhuman primates

    ✓ Peer-reviewed Hippocampus size on brain scans The Journal of neuroscience : the official journal of the Society for Neuroscience

    Key finding: These findings suggest that chronically elevated cortisol concentrations, in the absence of stress, do not produce hippocampal neuronal loss in nonhuman primates.

    Full summary, score breakdown and related studies → Original source

  15. 1999-03-01

    Sex and seasonal differences in the rate of cell proliferation in the dentate gyrus of adult wild meadow voles

    ✓ Peer-reviewed Hippocampus size on brain scans Neuroscience

    Key finding: We found that the number of [3H]thymidine-labeled cells varied across the seasons and across sex in the meadow vole. +4 more findings

    Full summary, score breakdown and related studies → Original source

  16. 1999-03-01

    Activation of receptor for advanced glycation end products: a mechanism for chronic vascular dysfunction in diabetic vasculopathy and atherosclerosis

    ✓ Peer-reviewed Disease mechanisms Circulation research

    Key finding: In a model of accelerated atherosclerosis associated with diabetes in genetically manipulated mice, blockade of cell surface RAGE by infusion of a soluble, truncated form of the receptor completely suppressed enhanced formation of vascular lesions. +1 more finding

    Full summary, score breakdown and related studies → Original source

  17. 1999-03-01

    Tangles and plaques in nondemented aging and ?preclinical? Alzheimer's disease

    ✓ Peer-reviewed Brain tissue and pathology Annals of Neurology

    Key finding: Tangles were found in all the nondemented cases, especially in hippocampal and parahippocampal areas; the average tangle concentration increased exponentially with age. +4 more findings

    Full summary, score breakdown and related studies → Original source

  18. 1999-03-01

    Insight in dementia: when does it occur? Evidence for a nonlinear relationship between insight and cognitive status

    ✓ Peer-reviewed Cognitive tests and assessment The journals of gerontology. Series B, Psychological sciences and social sciences

    Key finding: The aim of this study was to evaluate insight in a group of demented patients with two assessment scales and to assess their relationship with the cognitive level of disease severity. +3 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →