Newest studies

Volumetry of hippocampus and amygdala with high-resolution MRI and three-dimensional analysis software: minimizing the discrepancies between laboratories

41/100 ✓ Peer-reviewed Hippocampus size on brain scans Cerebral cortex (New York, N.Y. : 1991)

Key finding: However, different data acquisition techniques, analysis software and anatomical boundaries have in the past made it difficult to compare results of MRI studies from different laboratories. +3 more findings

• Brain Scans

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Navigation-related structural change in the hippocampi of taxi drivers

36/100 ✓ Peer-reviewed Hippocampus size on brain scans Proceedings of the National Academy of Sciences of the United States of America

Key finding: Structural MRIs of the brains of humans with extensive navigation experience, licensed London taxi drivers, were analyzed and compared with those of control subjects who did not drive taxis. +1 more finding

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Selecting target conditions for quality of care improvement in vulnerable older adults

36/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society

Key finding: The 21 conditions selected as targets for quality improvement among vulnerable older adults include (in rank order): pharmacologic management; depression; dementia; heart failure; stroke (and atrial fibrillation); hospitalization and surgery; falls and mobility disorders; diabetes mellitus; end-of-life care; ischemic heart disease; hypertension; pressure ulcers; osteoporosis; urinary incontinence; pain management; preventive services; hearing impairment; pneumonia and influenza; vision impairment; malnutrition; and osteoarthritis.

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A decamer duplication in the 3' region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred

50/100 ✓ Peer-reviewed Brain tissue and pathology Proceedings of the National Academy of Sciences of the United States of America

Key finding: Neuropathological findings include severe widespread cerebral amyloid angiopathy, hippocampal plaques, and neurofibrillary tangles, similar to Alzheimer's disease. +3 more findings

• Genetics
• Brain Biology

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A 10-year study of the incidence of and factors predicting dementia in Parkinson's disease

54/100 ✓ Peer-reviewed Brain tissue and pathology Neurology

Key finding: The authors recruited 83 patients with PD and 50 controls, all without dementia at initial assessment, and assessed them at regular intervals over a maximum period of 122 months. +3 more findings

• Risk Factors

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What clinical features are most useful to distinguish definite multiple system atrophy from Parkinson's disease?

48/100 ✓ Peer-reviewed Digital health tools Journal of neurology, neurosurgery, and psychiatry

Key finding: Predictive models may help differentiate MSA and PD premortem.

• Other Dementias

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Intake of flavonoids and risk of dementia

54/100 ✓ Peer-reviewed How common it is European journal of epidemiology

Key finding: We investigated whether flavonoid intake could be associated with a lower incidence of dementia in a cohort of 1367 subjects above 65 years of age (Paquid). +2 more findings

• Risk Factors

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A cross-national survey of tube-feeding decisions in cognitively impaired older persons

48/100 ✓ Peer-reviewed Disparities Journal of the American Geriatrics Society

Key finding: Despite the difference in diagnostic indication for tube-feeding, the substitute decision-making process was seriously limited at both sites by poor implementation of the principle of substituted judgement, a need for broader advance directives, and improved transfer of knowledge between clinicians and decision-makers.

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The cognitive correlates of white matter abnormalities in normal aging: a quantitative review

61/100 ✓ Peer-reviewed Caregiving Neuropsychology

Key finding: Cerebral white matter of asymptomatic people frequently exhibits circumscribed areas of hyperintensity on magnetic resonance (MR) images and hypodensity on computed tomography scans. +1 more finding

• Brain Scans

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Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease

59/100 ✓ Peer-reviewed Getting a diagnosis Annals of neurology

Key finding: When the normals were compared with the individuals with memory impairments who ultimately developed AD (the converters), the accuracy of discrimination was 93%, based on the MRI measures at baseline (sensitivity = 0.95; specificity = 0.90).

• Brain Scans

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Influence of social network on occurrence of dementia: a community-based longitudinal study

62/100 ✓ Peer-reviewed Prevention and risk Lancet (London, England)

Key finding: Those individuals living alone, and those without any close social ties, both had an adjusted relative risk for developing dementia of 1.5 (95% CI 1.0-2.1 and 1.0-2.4, respectively). +1 more finding

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Cerebrospinal Fluid Biomarkers for Alzheimer's Disease: Their Role in Clinical Chemistry

38/100 ✓ Peer-reviewed Tau biomarkers EJIFCC

Key finding: In view of current (AChE inhibitors) and future (e.g. anti-Aβ aggregators), development and evaluation of cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease (AD) has become a rapidly growing research field. +4 more findings

• Biomarkers

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Cerebral amyloid angiopathy: an overview

38/100 ✓ Peer-reviewed Vascular contributions Neuropathology : official journal of the Japanese Society of Neuropathology

Key finding: Cerebral amyloid angiopathy (CAA) is characterized by amyloid deposition in cortical and leptomeningeal vessels. +4 more findings

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Effects of individualized versus classical "relaxation" music on the frequency of agitation in elderly persons with Alzheimer's disease and related disorders

43/100 ✓ Peer-reviewed Health systems and care delivery International psychogeriatrics

Key finding: A repeated measures analysis of variance with Bonferroni post hoc test showed a significant reduction in agitation during and following individualized music compared to classical music.

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Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline

59/100 ✓ Peer-reviewed Brain tissue and pathology JAMA

Key finding: In this study, levels of total A(beta)x-40 and A(beta)x-42 were elevated early in dementia and levels of both peptides were strongly correlated with cognitive decline. +3 more findings

• Brain Biology

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Development of a minimum data set-based depression rating scale for use in nursing homes

45/100 ✓ Peer-reviewed Risk factors Age and ageing

Key finding: There is a need for a standardized screening instrument which incorporates daily observations of nursing-home staff. +1 more finding

• Care Services

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Donepezil hydrochloride (E2020) and other acetylcholinesterase inhibitors

36/100 ✓ Peer-reviewed Treatments Current medicinal chemistry

Key finding: The successful development of these compounds was based on a well-accepted theory that the decline in cognitive and mental functions associated with AD is related to the loss of cortical cholinergic neurotransmission.

• Treatments

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Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid

36/100 ✓ Peer-reviewed Risk genes beyond APOE Biochemistry

Key finding: One of the mutant forms of alpha-synuclein (A53T) fibrillizes more rapidly in vitro than does the wild-type protein, suggesting that a correlation may exist between the rate of in vitro fibrillization and/or oligomerization and the progression of PD, analogous to the relationship between Abeta fibrillization in vitro and familial AD. +2 more findings

• Genetics
• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

The capacity of people with a 'mental disability' to make a health care decision

43/100 ✓ Peer-reviewed Biomarkers Psychological medicine

Key finding: Consistent with current views, capacity reflected an interaction between the decision-maker and the demands of the decision-making task. +1 more finding

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The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients

36/100 ✓ Peer-reviewed Vascular contributions The Journal of clinical investigation

Key finding: In CADASIL brains, we found evidence of a dramatic and selective accumulation of the 210-kDa Notch3 cleavage product. +1 more finding

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Association of vitamin E and C supplement use with cognitive function and dementia in elderly men

66/100 ✓ Peer-reviewed Brain tissue and pathology Neurology

Key finding: The Honolulu-Asia Aging Study is a longitudinal study of Japanese-American men living in Hawaii. +3 more findings

• Lifestyle

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APOE and the risk of PD with or without dementia in a population-based study

56/100 ✓ Peer-reviewed Long-term cohort studies Neurology

Key finding: The study formed part of the Rotterdam Study, a prospective, population-based cohort study on the frequency, etiology, and prognosis of chronic diseases. +3 more findings

• Genetics

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The quality of life in Parkinson's disease

46/100 ✓ Peer-reviewed Cognitive tests and assessment Movement disorders : official journal of the Movement Disorder Society

Key finding: Associations to the variables age, age at onset, duration, clinical stage (Hoehn and Yahr), depression (Zung), and dementia (MMSE) were studied. +3 more findings

• Other Dementias

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Alzheimer's disease in the parents of women with trisomic spontaneous abortions

37/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Neuroreport

Key finding: We compared rates of Alzheimer-like dementia in the parents of women with trisomic pregnancy losses (n = 109) with those in parents of women with chromosomally normal losses (n = 151) and births (n = 216). +4 more findings

• Down Syndrome

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[The Mini-Mental State Examination as a selected diagnostic test for dementia: a Colombian population study. GENECO]

43/100 ✓ Peer-reviewed Disparities Revista de neurologia

Key finding: Twelve cases of dementia were diagnosed among individuals with scores below cutoff point and one among subjects with high scores. +1 more finding

• Diagnosis
• Clinical Trials

Full summary, score breakdown and related studies → Original source