Topic: Amyloid, tau and blood-test diagnosis
Neben ihrer Wirkung auf Gewichtskontrolle und kardiometabolische Parameter könnten GLP-1RA auch die endokrine Funktion von Adipozyten sowie die chronische Inflammation bei der Adipositas und damit die Entstehung adipositasassoziierter Tumoren modulieren. Um zu erfahren, wo die Grenze zwischen Fact und Fiction liegt, benötigen wir prospektive Studien zur onkologischen Bedeutung von GLP-1RA und ihren genetischen, metabolischen und inflammatorischen Mechanismen. Sie könnten ein besseres Verständnis zur Pathogenese beider Erkrankungen und neue therapeutische Ansätze eröffnen. Alexander Kretzschmar, München Publication History Article published online: 27 November 2025 © 2025. Georg Thieme Verlag KG Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany
Key findings
- Neben ihrer Wirkung auf Gewichtskontrolle und kardiometabolische Parameter könnten GLP-1RA auch die endokrine Funktion von Adipozyten sowie die chronische Inflammation bei der Adipositas und damit die Entstehung adipositasassoziierter Tumoren modulieren.
- Um zu erfahren, wo die Grenze zwischen Fact und Fiction liegt, benötigen wir prospektive Studien zur onkologischen Bedeutung von GLP-1RA und ihren genetischen, metabolischen und inflammatorischen Mechanismen.
- Sie könnten ein besseres Verständnis zur Pathogenese beider Erkrankungen und neue therapeutische Ansätze eröffnen.
- Alexander Kretzschmar, München Publication History Article published online: 27 November 2025 © 2025.
- Georg Thieme Verlag KG Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany
Why it matters
This German-language article discusses whether GLP-1 receptor agonists might modulate adipose tissue endocrine function and chronic inflammation in obesity, and thereby the development of obesity-associated tumors. It states that prospective studies are needed to determine the boundary between fact and fiction regarding the oncological significance of these drugs.
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Study details
- Participants3,021,508
- Evidence strengthLow
How this study scored 32/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on senior author's track record and institution's track record, so those were left out: it earned 30 of the 93 points we could judge it on, which is 32 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Onkologische Welt) |
| Journal's citation record | 0 / 4 | Onkologische Welt: journal h-index 10 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 4 / 4 | 3,021,508 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 0 / 7 | Cited 0 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 0 / 6 | Cited 0.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 0 institution(s) in 0 countries — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 30 / 93 | Scored on 18 of 20 parts. We have no data for the rest, so they are left out: 30 of the 93 points we could judge it on is 32 out of 100. |
| Total | 32 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Kretzschmar, A. (2025). Alzheimer und Tumoren – eine komplexe Beziehung. Onkologische Welt. https://doi.org/10.1055/a-2526-4099
Vancouver
Kretzschmar A. Alzheimer und Tumoren – eine komplexe Beziehung. Onkologische Welt. 2025. doi:10.1055/a-2526-4099.
BibTeX
@article{kretzschmar2025-7afc0ba9,
author = {Kretzschmar, Alexander},
title = {{Alzheimer und Tumoren – eine komplexe Beziehung}},
journal = {Onkologische Welt},
year = {2025},
doi = {10.1055/a-2526-4099},
url = {https://doi.org/10.1055/a-2526-4099}
}
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