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Apolipoprotein E genotype and cardiovascular disease in the Framingham Heart Study
Lahoz C, Schaefer EJ, Cupples LA, Wilson PW, Levy D, Osgood D, Parpos S, Pedro-Botet J et al.. Atherosclerosis, 2001-02-01
Topic: Brain proteins, microglia and lab models
Background Apolipoprotein (apo) E is a constituent of lipoproteins with considerable variation due to cysteine-arginine exchanges. The apo E4 (Arg112-Cys) polymorphism has been associated with dementia and hypercholesterolemia. We investigated the relation of APOE genotype to cardiovascular disease (CVD) in the Framingham Offspring Study.
Key findings
- The apo E4 (Arg112-Cys) polymorphism has been associated with dementia and hypercholesterolemia.
- We investigated the relation of APOE genotype to cardiovascular disease (CVD) in the Framingham Offspring Study.
- Methods and results DNA was isolated from 3413 study participants and APOE genotypes were determined utilizing the polymerase chain reaction and restriction isotyping.
- In the entire group of subjects, 20.7% had apo E4/4 or E3/4 (Group E4); 14.1% had apo E2/2 or E2/3 (Group E2) and 63.9% had the apo E3/3 genotype (Group E3).
Why it matters
This study examined the relationship between APOE genotype, a gene variant linked to dementia and high cholesterol, and cardiovascular disease in 3,413 participants of the Framingham Offspring Study. It explored shared risk factors between heart disease and dementia but did not test any treatment.
Study details
- Effect size20.7%; 14.1%; 63.9%
- Evidence strengthLow
How this study scored 49/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Atherosclerosis) |
| Journal's citation record | 2 / 4 | Atherosclerosis: journal h-index 247 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2001 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 319 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 11.8 citations a year over 27 year(s) since 2001 |
| Impact for its field and year | 4 / 6 | Cited 16.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 8 other studies in this library |
| Still being cited | 2 / 4 | Cited 24 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author José María Ordovás: h-index 136 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Boston University: institution h-index 1,456 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 11257253) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 49 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Lahoz, C., Schaefer, E. J., Cupples, L. A., Wilson, P. W., Levy, D., Osgood, D., et al. (2001). Apolipoprotein E genotype and cardiovascular disease in the Framingham Heart Study. Atherosclerosis. https://doi.org/10.1016/s0021-9150(00)00570-0
Vancouver
Lahoz C, Schaefer EJ, Cupples LA, Wilson PW, Levy D, Osgood D, et al. Apolipoprotein E genotype and cardiovascular disease in the Framingham Heart Study. Atherosclerosis. 2001. doi:10.1016/s0021-9150(00)00570-0. PMID: 11257253.
BibTeX
@article{lahoz2001-11257253,
author = {Lahoz, C. and Schaefer, E. J. and Cupples, L. A. and Wilson, P. W. and Levy, D. and Osgood, D. and Parpos, S. and Pedro-Botet, J. and others},
title = {{Apolipoprotein E genotype and cardiovascular disease in the Framingham Heart Study}},
journal = {Atherosclerosis},
year = {2001},
doi = {10.1016/s0021-9150(00)00570-0},
pmid = {11257253},
url = {https://doi.org/10.1016/s0021-9150(00)00570-0}
}
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